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Elite athletes’ genetic predisposition for altered risk of complex metabolic traits

BACKGROUND: Genetic variants may predispose humans to elevated risk of common metabolic morbidities such as obesity and Type 2 Diabetes (T2D). Some of these variants have also been shown to influence elite athletic performance and the response to exercise training. We compared the genotype distribut...

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Autores principales: Banting, Lauren K, Pushkarev, Vladimir P, Cieszczyk, Pawel, Zarebska, Aleksandra, Maciejewska-Karlowska, Agnieszka, Sawczuk, M-arek, Leońska-Duniec, Agata, Dyatlov, Dmitry A, Orekhov, Evgeniy F, Degtyarev, Aleksandr V, Pushkareva, Yuliya E, Yan, Xu, Birk, Ruth, Eynon, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320608/
https://www.ncbi.nlm.nih.gov/pubmed/25612568
http://dx.doi.org/10.1186/s12864-014-1199-0
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author Banting, Lauren K
Pushkarev, Vladimir P
Cieszczyk, Pawel
Zarebska, Aleksandra
Maciejewska-Karlowska, Agnieszka
Sawczuk, M-arek
Leońska-Duniec, Agata
Dyatlov, Dmitry A
Orekhov, Evgeniy F
Degtyarev, Aleksandr V
Pushkareva, Yuliya E
Yan, Xu
Birk, Ruth
Eynon, Nir
author_facet Banting, Lauren K
Pushkarev, Vladimir P
Cieszczyk, Pawel
Zarebska, Aleksandra
Maciejewska-Karlowska, Agnieszka
Sawczuk, M-arek
Leońska-Duniec, Agata
Dyatlov, Dmitry A
Orekhov, Evgeniy F
Degtyarev, Aleksandr V
Pushkareva, Yuliya E
Yan, Xu
Birk, Ruth
Eynon, Nir
author_sort Banting, Lauren K
collection PubMed
description BACKGROUND: Genetic variants may predispose humans to elevated risk of common metabolic morbidities such as obesity and Type 2 Diabetes (T2D). Some of these variants have also been shown to influence elite athletic performance and the response to exercise training. We compared the genotype distribution of five genetic Single Nucleotide Polymorphisms (SNPs) known to be associated with obesity and obesity co-morbidities (IGF2BP2 rs4402960, LPL rs320, LPL rs328, KCJN rs5219, and MTHFR rs1801133) between athletes (all male, n = 461; endurance athletes n = 254, sprint/power athletes n = 207), and controls (all male, n = 544) in Polish and Russian samples. We also examined the association between these SNPs and the athletes’ competition level (‘elite’ and ‘national’ level). Genotypes were analysed by Single-Base Extension and Real-Time PCR. Multinomial logistic regression analyses were conducted to assess the association between genotypes and athletic status/competition level. RESULTS: IGF2BP2 rs4402960 and LPL rs320 were significantly associated with athletic status; sprint/power athletes were twice more likely to have the IGF2BP2 rs4402960 risk (T) allele compared to endurance athletes (OR = 2.11, 95% CI = 1.03-4.30, P <0.041), and non-athletic controls were significantly less likely to have the T allele compared to sprint/power athletes (OR = 0.62, 95% CI =0.43-0.89, P <0.0009). The control group was significantly more likely to have the LPL rs320 risk (G) allele compared to endurance athletes (OR = 1.26, 95% CI = 1.05-1.52, P <0.013). Hence, endurance athletes were the “protected” group being significantly (p < 0.05) less likely to have the risk allele compared to sprint/power athletes (IGF2BP2 rs4402960) and significantly (p < 0.05) less likely to have the risk allele compared to controls (LPL rs320). The other 3 SNPs did not show significant differences between the study groups. CONCLUSIONS: Male endurance athletes are less likely to have the metabolic risk alleles of IGF2BP2 rs4402960 and LPL rs320, compared to sprint/power athletes and controls, respectively. These results suggest that some SNPs across the human genome have a dual effect and may predispose endurance athletes to reduced risk of developing metabolic morbidities, whereas sprint/power athletes might be predisposed to elevated risk.
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spelling pubmed-43206082015-02-08 Elite athletes’ genetic predisposition for altered risk of complex metabolic traits Banting, Lauren K Pushkarev, Vladimir P Cieszczyk, Pawel Zarebska, Aleksandra Maciejewska-Karlowska, Agnieszka Sawczuk, M-arek Leońska-Duniec, Agata Dyatlov, Dmitry A Orekhov, Evgeniy F Degtyarev, Aleksandr V Pushkareva, Yuliya E Yan, Xu Birk, Ruth Eynon, Nir BMC Genomics Research Article BACKGROUND: Genetic variants may predispose humans to elevated risk of common metabolic morbidities such as obesity and Type 2 Diabetes (T2D). Some of these variants have also been shown to influence elite athletic performance and the response to exercise training. We compared the genotype distribution of five genetic Single Nucleotide Polymorphisms (SNPs) known to be associated with obesity and obesity co-morbidities (IGF2BP2 rs4402960, LPL rs320, LPL rs328, KCJN rs5219, and MTHFR rs1801133) between athletes (all male, n = 461; endurance athletes n = 254, sprint/power athletes n = 207), and controls (all male, n = 544) in Polish and Russian samples. We also examined the association between these SNPs and the athletes’ competition level (‘elite’ and ‘national’ level). Genotypes were analysed by Single-Base Extension and Real-Time PCR. Multinomial logistic regression analyses were conducted to assess the association between genotypes and athletic status/competition level. RESULTS: IGF2BP2 rs4402960 and LPL rs320 were significantly associated with athletic status; sprint/power athletes were twice more likely to have the IGF2BP2 rs4402960 risk (T) allele compared to endurance athletes (OR = 2.11, 95% CI = 1.03-4.30, P <0.041), and non-athletic controls were significantly less likely to have the T allele compared to sprint/power athletes (OR = 0.62, 95% CI =0.43-0.89, P <0.0009). The control group was significantly more likely to have the LPL rs320 risk (G) allele compared to endurance athletes (OR = 1.26, 95% CI = 1.05-1.52, P <0.013). Hence, endurance athletes were the “protected” group being significantly (p < 0.05) less likely to have the risk allele compared to sprint/power athletes (IGF2BP2 rs4402960) and significantly (p < 0.05) less likely to have the risk allele compared to controls (LPL rs320). The other 3 SNPs did not show significant differences between the study groups. CONCLUSIONS: Male endurance athletes are less likely to have the metabolic risk alleles of IGF2BP2 rs4402960 and LPL rs320, compared to sprint/power athletes and controls, respectively. These results suggest that some SNPs across the human genome have a dual effect and may predispose endurance athletes to reduced risk of developing metabolic morbidities, whereas sprint/power athletes might be predisposed to elevated risk. BioMed Central 2015-01-23 /pmc/articles/PMC4320608/ /pubmed/25612568 http://dx.doi.org/10.1186/s12864-014-1199-0 Text en © Banting et al.; licensee Biomed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Banting, Lauren K
Pushkarev, Vladimir P
Cieszczyk, Pawel
Zarebska, Aleksandra
Maciejewska-Karlowska, Agnieszka
Sawczuk, M-arek
Leońska-Duniec, Agata
Dyatlov, Dmitry A
Orekhov, Evgeniy F
Degtyarev, Aleksandr V
Pushkareva, Yuliya E
Yan, Xu
Birk, Ruth
Eynon, Nir
Elite athletes’ genetic predisposition for altered risk of complex metabolic traits
title Elite athletes’ genetic predisposition for altered risk of complex metabolic traits
title_full Elite athletes’ genetic predisposition for altered risk of complex metabolic traits
title_fullStr Elite athletes’ genetic predisposition for altered risk of complex metabolic traits
title_full_unstemmed Elite athletes’ genetic predisposition for altered risk of complex metabolic traits
title_short Elite athletes’ genetic predisposition for altered risk of complex metabolic traits
title_sort elite athletes’ genetic predisposition for altered risk of complex metabolic traits
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320608/
https://www.ncbi.nlm.nih.gov/pubmed/25612568
http://dx.doi.org/10.1186/s12864-014-1199-0
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