Saxagliptin Restores Vascular Mitochondrial Exercise Response in the Goto-Kakizaki Rat

Cardiovascular disease risk and all-cause mortality are largely predicted by physical fitness. Exercise stimulates vascular mitochondrial biogenesis through endothelial nitric oxide synthase (eNOS), sirtuins, and PPARγ coactivator 1α (PGC-1α), a response absent in diabetes and hypertension. We hypot...

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Detalles Bibliográficos
Autores principales: Keller, Amy C., Knaub, Leslie A., Miller, Matthew W., Birdsey, Nicholas, Klemm, Dwight J., Reusch, Jane E. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of Cardiovascular Pharmacology 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320657/
https://www.ncbi.nlm.nih.gov/pubmed/25264749
http://dx.doi.org/10.1097/FJC.0000000000000170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320657/
https://www.ncbi.nlm.nih.gov/pubmed/25264749
http://dx.doi.org/10.1097/FJC.0000000000000170

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