Clinical utility of anti-lipoarabinomannan antibodies testing for the diagnosis of tuberculous arthritis

Diagnosis of extrapulmonary tuberculosis (TB) is often challenging. In this work we discuss the utility of an assay for Lipoarabinomannan (LAM) antibody detection in synovial fluid. LAM is one of the three major groups of lipopolysaccharides within the Mycobacterium tuberculosis (MTB) cell wall. An...

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Autores principales: Passiu, Giuseppe, Erre, Gian Luca, Pirina, Pietro, Sechi, Leonardo Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320688/
https://www.ncbi.nlm.nih.gov/pubmed/25674511
http://dx.doi.org/10.1186/s40064-015-0858-1
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author Passiu, Giuseppe
Erre, Gian Luca
Pirina, Pietro
Sechi, Leonardo Antonio
author_facet Passiu, Giuseppe
Erre, Gian Luca
Pirina, Pietro
Sechi, Leonardo Antonio
author_sort Passiu, Giuseppe
collection PubMed
description Diagnosis of extrapulmonary tuberculosis (TB) is often challenging. In this work we discuss the utility of an assay for Lipoarabinomannan (LAM) antibody detection in synovial fluid. LAM is one of the three major groups of lipopolysaccharides within the Mycobacterium tuberculosis (MTB) cell wall. An ELISA based test was used to investigate the presence of antibodies against LAM in an immunocompetent patient with knee arthritis. The symptoms resolved after isoniazid treatment. LAM positivity has been used as a diagnostic tool for TB in different settings, including veterinary field. The test could be of some value to diagnose tuberculous arthritis in selected patients when gold standard test returned negative although further investigations are welcome.
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spelling pubmed-43206882015-02-11 Clinical utility of anti-lipoarabinomannan antibodies testing for the diagnosis of tuberculous arthritis Passiu, Giuseppe Erre, Gian Luca Pirina, Pietro Sechi, Leonardo Antonio Springerplus Case Study Diagnosis of extrapulmonary tuberculosis (TB) is often challenging. In this work we discuss the utility of an assay for Lipoarabinomannan (LAM) antibody detection in synovial fluid. LAM is one of the three major groups of lipopolysaccharides within the Mycobacterium tuberculosis (MTB) cell wall. An ELISA based test was used to investigate the presence of antibodies against LAM in an immunocompetent patient with knee arthritis. The symptoms resolved after isoniazid treatment. LAM positivity has been used as a diagnostic tool for TB in different settings, including veterinary field. The test could be of some value to diagnose tuberculous arthritis in selected patients when gold standard test returned negative although further investigations are welcome. Springer International Publishing 2015-02-05 /pmc/articles/PMC4320688/ /pubmed/25674511 http://dx.doi.org/10.1186/s40064-015-0858-1 Text en © Passiu et al.; licensee Springer. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Case Study
Passiu, Giuseppe
Erre, Gian Luca
Pirina, Pietro
Sechi, Leonardo Antonio
Clinical utility of anti-lipoarabinomannan antibodies testing for the diagnosis of tuberculous arthritis
title Clinical utility of anti-lipoarabinomannan antibodies testing for the diagnosis of tuberculous arthritis
title_full Clinical utility of anti-lipoarabinomannan antibodies testing for the diagnosis of tuberculous arthritis
title_fullStr Clinical utility of anti-lipoarabinomannan antibodies testing for the diagnosis of tuberculous arthritis
title_full_unstemmed Clinical utility of anti-lipoarabinomannan antibodies testing for the diagnosis of tuberculous arthritis
title_short Clinical utility of anti-lipoarabinomannan antibodies testing for the diagnosis of tuberculous arthritis
title_sort clinical utility of anti-lipoarabinomannan antibodies testing for the diagnosis of tuberculous arthritis
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320688/
https://www.ncbi.nlm.nih.gov/pubmed/25674511
http://dx.doi.org/10.1186/s40064-015-0858-1
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