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Gestational diabetes mellitus and impaired glucose tolerance pregnant women

Objective: To evaluate correlations between insulin secretion and resistance in patients with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (GIGT). Methods: Three hundred thirty six pregnant women with an oral glucose tolerance test (OGTT) were tested and measured in...

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Autores principales: Wei, Jinhua, Gao, Jianbo, Cheng, Jinluo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publicaitons 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320700/
https://www.ncbi.nlm.nih.gov/pubmed/25674108
http://dx.doi.org/10.12669/pjms.306.5755
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author Wei, Jinhua
Gao, Jianbo
Cheng, Jinluo
author_facet Wei, Jinhua
Gao, Jianbo
Cheng, Jinluo
author_sort Wei, Jinhua
collection PubMed
description Objective: To evaluate correlations between insulin secretion and resistance in patients with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (GIGT). Methods: Three hundred thirty six pregnant women with an oral glucose tolerance test (OGTT) were tested and measured insulin function indices (IFI), insulin resistance indices (HOMA-IR) as well as blood serum triglycerides (TG), total cholesterol (TCH) and low density lipoprotein cholesterol (LDL-C) concentrations. GIGT patients were further divided into subgroups according to hyperglycemia appearance 1, 2 or 3 hours after glucose ingestion. Results: GDM and GIGT correlated with age (p<0.05), family history of diabetes (p<0.05) and pre-pregnancy body mass indices (BMIs) (p<0.05). Blood pressures were higher in GDM than in GIGT and normal glucose tolerance (NGT) patients (p<0.05). The IFIs were gradually reduced (p<0.05), whereas HOMA-IR was gradually enhanced (p<0.05) in the GIGT and GDM patients. Blood serum TG, TCH and LDL-C concentrations were higher in the GIGT and GDM groups (p<0.05) and the GIGT 1 hour hyperglycemia subgroup had highest pregnancy weight gain and HOMA-IR values (p<0.05). Conclusions : Advanced age, family history of diabetes, high BMIs and blood pressure were risk factors for GIGT and GDM, which were both caused by reduced insulin secretion and enhanced insulin resistance.
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spelling pubmed-43207002015-02-11 Gestational diabetes mellitus and impaired glucose tolerance pregnant women Wei, Jinhua Gao, Jianbo Cheng, Jinluo Pak J Med Sci Original Article Objective: To evaluate correlations between insulin secretion and resistance in patients with gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (GIGT). Methods: Three hundred thirty six pregnant women with an oral glucose tolerance test (OGTT) were tested and measured insulin function indices (IFI), insulin resistance indices (HOMA-IR) as well as blood serum triglycerides (TG), total cholesterol (TCH) and low density lipoprotein cholesterol (LDL-C) concentrations. GIGT patients were further divided into subgroups according to hyperglycemia appearance 1, 2 or 3 hours after glucose ingestion. Results: GDM and GIGT correlated with age (p<0.05), family history of diabetes (p<0.05) and pre-pregnancy body mass indices (BMIs) (p<0.05). Blood pressures were higher in GDM than in GIGT and normal glucose tolerance (NGT) patients (p<0.05). The IFIs were gradually reduced (p<0.05), whereas HOMA-IR was gradually enhanced (p<0.05) in the GIGT and GDM patients. Blood serum TG, TCH and LDL-C concentrations were higher in the GIGT and GDM groups (p<0.05) and the GIGT 1 hour hyperglycemia subgroup had highest pregnancy weight gain and HOMA-IR values (p<0.05). Conclusions : Advanced age, family history of diabetes, high BMIs and blood pressure were risk factors for GIGT and GDM, which were both caused by reduced insulin secretion and enhanced insulin resistance. Professional Medical Publicaitons 2014 /pmc/articles/PMC4320700/ /pubmed/25674108 http://dx.doi.org/10.12669/pjms.306.5755 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Wei, Jinhua
Gao, Jianbo
Cheng, Jinluo
Gestational diabetes mellitus and impaired glucose tolerance pregnant women
title Gestational diabetes mellitus and impaired glucose tolerance pregnant women
title_full Gestational diabetes mellitus and impaired glucose tolerance pregnant women
title_fullStr Gestational diabetes mellitus and impaired glucose tolerance pregnant women
title_full_unstemmed Gestational diabetes mellitus and impaired glucose tolerance pregnant women
title_short Gestational diabetes mellitus and impaired glucose tolerance pregnant women
title_sort gestational diabetes mellitus and impaired glucose tolerance pregnant women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320700/
https://www.ncbi.nlm.nih.gov/pubmed/25674108
http://dx.doi.org/10.12669/pjms.306.5755
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