Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application**

We show that bimetallic nanoparticles (NPs) of AuPt without any surface modification are potent antibiotic reagents, while pure Au NPs or pure Pt NPs display no antibiotic activities. The most potent antibacterial AuPt NPs happen to be the most effective catalysts for chemical transformations. The m...

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Detalles Bibliográficos
Autores principales: Zhao, Yuyun, Ye, Chunjie, Liu, Wenwen, Chen, Rong, Jiang, Xingyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320751/
https://www.ncbi.nlm.nih.gov/pubmed/24828967
http://dx.doi.org/10.1002/anie.201401035
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author Zhao, Yuyun
Ye, Chunjie
Liu, Wenwen
Chen, Rong
Jiang, Xingyu
author_facet Zhao, Yuyun
Ye, Chunjie
Liu, Wenwen
Chen, Rong
Jiang, Xingyu
author_sort Zhao, Yuyun
collection PubMed
description We show that bimetallic nanoparticles (NPs) of AuPt without any surface modification are potent antibiotic reagents, while pure Au NPs or pure Pt NPs display no antibiotic activities. The most potent antibacterial AuPt NPs happen to be the most effective catalysts for chemical transformations. The mechanism of antibiotic action includes the dissipation of membrane potential and the elevation of adenosine triphosphate (ATP) levels. These bimetallic NPs are unique in that they do not produce reactive oxygen species as most antibiotics do. Being non-toxic to human cells, these bimetallic noble NPs might open an entry to a new class of antibiotics.
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spelling pubmed-43207512015-02-13 Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application** Zhao, Yuyun Ye, Chunjie Liu, Wenwen Chen, Rong Jiang, Xingyu Angew Chem Int Ed Engl Communications We show that bimetallic nanoparticles (NPs) of AuPt without any surface modification are potent antibiotic reagents, while pure Au NPs or pure Pt NPs display no antibiotic activities. The most potent antibacterial AuPt NPs happen to be the most effective catalysts for chemical transformations. The mechanism of antibiotic action includes the dissipation of membrane potential and the elevation of adenosine triphosphate (ATP) levels. These bimetallic NPs are unique in that they do not produce reactive oxygen species as most antibiotics do. Being non-toxic to human cells, these bimetallic noble NPs might open an entry to a new class of antibiotics. WILEY-VCH Verlag 2014-07-28 2014-05-14 /pmc/articles/PMC4320751/ /pubmed/24828967 http://dx.doi.org/10.1002/anie.201401035 Text en © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Communications
Zhao, Yuyun
Ye, Chunjie
Liu, Wenwen
Chen, Rong
Jiang, Xingyu
Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application**
title Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application**
title_full Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application**
title_fullStr Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application**
title_full_unstemmed Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application**
title_short Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application**
title_sort tuning the composition of aupt bimetallic nanoparticles for antibacterial application**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320751/
https://www.ncbi.nlm.nih.gov/pubmed/24828967
http://dx.doi.org/10.1002/anie.201401035
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