Total Synthesis of Jiadifenolide**

As a potent neurotrophic agent, the sesquiterpenoid jiadifenolide represents a valuable small-molecule lead for the potential therapeutic treatment of neurodegenerative diseases. A stereocontrolled total synthesis of this densely functionalized natural product is reported, central to which is an adv...

Descripción completa

Detalles Bibliográficos
Autores principales: Paterson, Ian, Xuan, Mengyang, Dalby, Stephen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320761/
https://www.ncbi.nlm.nih.gov/pubmed/24861364
http://dx.doi.org/10.1002/anie.201404224
_version_ 1782356178839273472
author Paterson, Ian
Xuan, Mengyang
Dalby, Stephen M
author_facet Paterson, Ian
Xuan, Mengyang
Dalby, Stephen M
author_sort Paterson, Ian
collection PubMed
description As a potent neurotrophic agent, the sesquiterpenoid jiadifenolide represents a valuable small-molecule lead for the potential therapeutic treatment of neurodegenerative diseases. A stereocontrolled total synthesis of this densely functionalized natural product is reported, central to which is an adventurous samarium-mediated cyclization reaction to establish the tricyclic core and the adjacent C5 and C6 quaternary stereocenters.
format Online
Article
Text
id pubmed-4320761
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher WILEY-VCH Verlag
record_format MEDLINE/PubMed
spelling pubmed-43207612015-02-13 Total Synthesis of Jiadifenolide** Paterson, Ian Xuan, Mengyang Dalby, Stephen M Angew Chem Int Ed Engl Communications As a potent neurotrophic agent, the sesquiterpenoid jiadifenolide represents a valuable small-molecule lead for the potential therapeutic treatment of neurodegenerative diseases. A stereocontrolled total synthesis of this densely functionalized natural product is reported, central to which is an adventurous samarium-mediated cyclization reaction to establish the tricyclic core and the adjacent C5 and C6 quaternary stereocenters. WILEY-VCH Verlag 2014-07-07 2014-05-23 /pmc/articles/PMC4320761/ /pubmed/24861364 http://dx.doi.org/10.1002/anie.201404224 Text en © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Paterson, Ian
Xuan, Mengyang
Dalby, Stephen M
Total Synthesis of Jiadifenolide**
title Total Synthesis of Jiadifenolide**
title_full Total Synthesis of Jiadifenolide**
title_fullStr Total Synthesis of Jiadifenolide**
title_full_unstemmed Total Synthesis of Jiadifenolide**
title_short Total Synthesis of Jiadifenolide**
title_sort total synthesis of jiadifenolide**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320761/
https://www.ncbi.nlm.nih.gov/pubmed/24861364
http://dx.doi.org/10.1002/anie.201404224
work_keys_str_mv AT patersonian totalsynthesisofjiadifenolide
AT xuanmengyang totalsynthesisofjiadifenolide
AT dalbystephenm totalsynthesisofjiadifenolide

Ejemplares similares