Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug

Inflammatory bowel disease (IBD) comprises several conditions with chronic or recurring immune response and inflammation of the gastrointestinal apparatus, of which ulcerative colitis and Crohn's disease are the commonest forms. This disease has a significant prevalence and it is of an unknown...

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Detalles Bibliográficos
Autores principales: Perrotta, Cristiana, Pellegrino, Paolo, Moroni, Eliana, De Palma, Clara, Cervia, Davide, Danelli, Piergiorgio, Clementi, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320793/
https://www.ncbi.nlm.nih.gov/pubmed/25685145
http://dx.doi.org/10.1155/2015/456895
Descripción
Sumario:Inflammatory bowel disease (IBD) comprises several conditions with chronic or recurring immune response and inflammation of the gastrointestinal apparatus, of which ulcerative colitis and Crohn's disease are the commonest forms. This disease has a significant prevalence and it is of an unknown aethiology. Five-aminosalicylic acid (5-ASA) and its derivatives are among the oldest drugs approved for the treatment of the IBD. In this review we reapprise aspects of 5-ASA mechanism of action, safety, and efficacy that in our opinion make it a valuable drug that can be fruitfully tailored in personalised treatments as a therapeutic option alongside other immune-modifying agents.

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