Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug

Inflammatory bowel disease (IBD) comprises several conditions with chronic or recurring immune response and inflammation of the gastrointestinal apparatus, of which ulcerative colitis and Crohn's disease are the commonest forms. This disease has a significant prevalence and it is of an unknown...

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Detalles Bibliográficos
Autores principales: Perrotta, Cristiana, Pellegrino, Paolo, Moroni, Eliana, De Palma, Clara, Cervia, Davide, Danelli, Piergiorgio, Clementi, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320793/
https://www.ncbi.nlm.nih.gov/pubmed/25685145
http://dx.doi.org/10.1155/2015/456895
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author Perrotta, Cristiana
Pellegrino, Paolo
Moroni, Eliana
De Palma, Clara
Cervia, Davide
Danelli, Piergiorgio
Clementi, Emilio
author_facet Perrotta, Cristiana
Pellegrino, Paolo
Moroni, Eliana
De Palma, Clara
Cervia, Davide
Danelli, Piergiorgio
Clementi, Emilio
author_sort Perrotta, Cristiana
collection PubMed
description Inflammatory bowel disease (IBD) comprises several conditions with chronic or recurring immune response and inflammation of the gastrointestinal apparatus, of which ulcerative colitis and Crohn's disease are the commonest forms. This disease has a significant prevalence and it is of an unknown aethiology. Five-aminosalicylic acid (5-ASA) and its derivatives are among the oldest drugs approved for the treatment of the IBD. In this review we reapprise aspects of 5-ASA mechanism of action, safety, and efficacy that in our opinion make it a valuable drug that can be fruitfully tailored in personalised treatments as a therapeutic option alongside other immune-modifying agents.
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spelling pubmed-43207932015-02-15 Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug Perrotta, Cristiana Pellegrino, Paolo Moroni, Eliana De Palma, Clara Cervia, Davide Danelli, Piergiorgio Clementi, Emilio Gastroenterol Res Pract Review Article Inflammatory bowel disease (IBD) comprises several conditions with chronic or recurring immune response and inflammation of the gastrointestinal apparatus, of which ulcerative colitis and Crohn's disease are the commonest forms. This disease has a significant prevalence and it is of an unknown aethiology. Five-aminosalicylic acid (5-ASA) and its derivatives are among the oldest drugs approved for the treatment of the IBD. In this review we reapprise aspects of 5-ASA mechanism of action, safety, and efficacy that in our opinion make it a valuable drug that can be fruitfully tailored in personalised treatments as a therapeutic option alongside other immune-modifying agents. Hindawi Publishing Corporation 2015 2015-01-21 /pmc/articles/PMC4320793/ /pubmed/25685145 http://dx.doi.org/10.1155/2015/456895 Text en Copyright © 2015 Cristiana Perrotta et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Perrotta, Cristiana
Pellegrino, Paolo
Moroni, Eliana
De Palma, Clara
Cervia, Davide
Danelli, Piergiorgio
Clementi, Emilio
Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug
title Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug
title_full Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug
title_fullStr Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug
title_full_unstemmed Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug
title_short Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug
title_sort five-aminosalicylic acid: an update for the reappraisal of an old drug
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320793/
https://www.ncbi.nlm.nih.gov/pubmed/25685145
http://dx.doi.org/10.1155/2015/456895
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