The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis

BACKGROUND: Voltage-gated Na(+) channels (VGSCs) are heteromeric protein complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits. VGSCs are classically expressed in electrically excitable cells, e.g. neurons. VGSCs are also expressed in tumour cells, including breast ca...

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Detalles Bibliográficos
Autores principales: Nelson, Michaela, Yang, Ming, Dowle, Adam A, Thomas, Jerry R, Brackenbury, William J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320839/
https://www.ncbi.nlm.nih.gov/pubmed/25623198
http://dx.doi.org/10.1186/s12943-014-0277-x

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