A Hybrid IMRT/VMAT Technique for the Treatment of Nasopharyngeal Cancer

Hybrid IMRT/VMAT technique which combined intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) was developed for the treatment of nasopharyngeal cancer (NPC). Two-full-arc VMAT (2ARC-VMAT), 9-field IMRT (9F-IMRT), and Hybrid IMRT/VMAT plans for NPC were compared in ter...

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Autores principales: Zhao, Nan, Yang, Ruijie, Jiang, Yuliang, Tian, Suqing, Guo, Fuxin, Wang, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320861/
https://www.ncbi.nlm.nih.gov/pubmed/25688371
http://dx.doi.org/10.1155/2015/940102
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author Zhao, Nan
Yang, Ruijie
Jiang, Yuliang
Tian, Suqing
Guo, Fuxin
Wang, Junjie
author_facet Zhao, Nan
Yang, Ruijie
Jiang, Yuliang
Tian, Suqing
Guo, Fuxin
Wang, Junjie
author_sort Zhao, Nan
collection PubMed
description Hybrid IMRT/VMAT technique which combined intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) was developed for the treatment of nasopharyngeal cancer (NPC). Two-full-arc VMAT (2ARC-VMAT), 9-field IMRT (9F-IMRT), and Hybrid IMRT/VMAT plans for NPC were compared in terms of the dosimetric quality, sparing of organs at risk (OARs), and delivery efficiency. The Hybrid IMRT/VMAT technique can improve the target dose homogeneity and conformity compared with 9F-IMRT and 2ARC-VMAT. It can reduce the dose delivered to the TMJ, mandible, temporal lobe, and unspecified tissue with fewer MUs compared with 9F-IMRT and dose delivered to parotids, brainstem, and spinal cord compared with 2ARC-VMAT technique. The mean delivery time of Hybrid plans was shorter than that of 9F-IMRT plans (408 s versus 812 s; P = 0.00) and longer than that of 2ARC-VMAT plans (408 s versus 179 s; P = 0.00). Hybrid IMRT/VMAT technique could be a viable radiotherapy technique with better plan quality.
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spelling pubmed-43208612015-02-16 A Hybrid IMRT/VMAT Technique for the Treatment of Nasopharyngeal Cancer Zhao, Nan Yang, Ruijie Jiang, Yuliang Tian, Suqing Guo, Fuxin Wang, Junjie Biomed Res Int Research Article Hybrid IMRT/VMAT technique which combined intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) was developed for the treatment of nasopharyngeal cancer (NPC). Two-full-arc VMAT (2ARC-VMAT), 9-field IMRT (9F-IMRT), and Hybrid IMRT/VMAT plans for NPC were compared in terms of the dosimetric quality, sparing of organs at risk (OARs), and delivery efficiency. The Hybrid IMRT/VMAT technique can improve the target dose homogeneity and conformity compared with 9F-IMRT and 2ARC-VMAT. It can reduce the dose delivered to the TMJ, mandible, temporal lobe, and unspecified tissue with fewer MUs compared with 9F-IMRT and dose delivered to parotids, brainstem, and spinal cord compared with 2ARC-VMAT technique. The mean delivery time of Hybrid plans was shorter than that of 9F-IMRT plans (408 s versus 812 s; P = 0.00) and longer than that of 2ARC-VMAT plans (408 s versus 179 s; P = 0.00). Hybrid IMRT/VMAT technique could be a viable radiotherapy technique with better plan quality. Hindawi Publishing Corporation 2015 2015-01-21 /pmc/articles/PMC4320861/ /pubmed/25688371 http://dx.doi.org/10.1155/2015/940102 Text en Copyright © 2015 Nan Zhao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhao, Nan
Yang, Ruijie
Jiang, Yuliang
Tian, Suqing
Guo, Fuxin
Wang, Junjie
A Hybrid IMRT/VMAT Technique for the Treatment of Nasopharyngeal Cancer
title A Hybrid IMRT/VMAT Technique for the Treatment of Nasopharyngeal Cancer
title_full A Hybrid IMRT/VMAT Technique for the Treatment of Nasopharyngeal Cancer
title_fullStr A Hybrid IMRT/VMAT Technique for the Treatment of Nasopharyngeal Cancer
title_full_unstemmed A Hybrid IMRT/VMAT Technique for the Treatment of Nasopharyngeal Cancer
title_short A Hybrid IMRT/VMAT Technique for the Treatment of Nasopharyngeal Cancer
title_sort hybrid imrt/vmat technique for the treatment of nasopharyngeal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320861/
https://www.ncbi.nlm.nih.gov/pubmed/25688371
http://dx.doi.org/10.1155/2015/940102
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