Cargando…

Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview

Experimental models of diabetic retinopathy (DR) have had a crucial role in the comprehension of the pathophysiology of the disease and the identification of new therapeutic strategies. Most of these studies have been conducted in vivo, in animal models. However, a significant contribution has also...

Descripción completa

Detalles Bibliográficos
Autores principales: Matteucci, Andrea, Varano, Monica, Mallozzi, Cinzia, Gaddini, Lucia, Villa, Marika, Gabrielli, Sara, Formisano, Giuseppe, Pricci, Flavia, Malchiodi-Albedi, Fiorella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320900/
https://www.ncbi.nlm.nih.gov/pubmed/25688355
http://dx.doi.org/10.1155/2015/364924
_version_ 1782356210536677376
author Matteucci, Andrea
Varano, Monica
Mallozzi, Cinzia
Gaddini, Lucia
Villa, Marika
Gabrielli, Sara
Formisano, Giuseppe
Pricci, Flavia
Malchiodi-Albedi, Fiorella
author_facet Matteucci, Andrea
Varano, Monica
Mallozzi, Cinzia
Gaddini, Lucia
Villa, Marika
Gabrielli, Sara
Formisano, Giuseppe
Pricci, Flavia
Malchiodi-Albedi, Fiorella
author_sort Matteucci, Andrea
collection PubMed
description Experimental models of diabetic retinopathy (DR) have had a crucial role in the comprehension of the pathophysiology of the disease and the identification of new therapeutic strategies. Most of these studies have been conducted in vivo, in animal models. However, a significant contribution has also been provided by studies on retinal cultures, especially regarding the effects of the potentially toxic components of the diabetic milieu on retinal cell homeostasis, the characterization of the mechanisms on the basis of retinal damage, and the identification of potentially protective molecules. In this review, we highlight the contribution given by primary retinal cultures to the study of DR, focusing on early neuroglial impairment. We also speculate on possible themes into which studies based on retinal cell cultures could provide deeper insight.
format Online
Article
Text
id pubmed-4320900
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-43209002015-02-16 Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview Matteucci, Andrea Varano, Monica Mallozzi, Cinzia Gaddini, Lucia Villa, Marika Gabrielli, Sara Formisano, Giuseppe Pricci, Flavia Malchiodi-Albedi, Fiorella Biomed Res Int Review Article Experimental models of diabetic retinopathy (DR) have had a crucial role in the comprehension of the pathophysiology of the disease and the identification of new therapeutic strategies. Most of these studies have been conducted in vivo, in animal models. However, a significant contribution has also been provided by studies on retinal cultures, especially regarding the effects of the potentially toxic components of the diabetic milieu on retinal cell homeostasis, the characterization of the mechanisms on the basis of retinal damage, and the identification of potentially protective molecules. In this review, we highlight the contribution given by primary retinal cultures to the study of DR, focusing on early neuroglial impairment. We also speculate on possible themes into which studies based on retinal cell cultures could provide deeper insight. Hindawi Publishing Corporation 2015 2015-01-19 /pmc/articles/PMC4320900/ /pubmed/25688355 http://dx.doi.org/10.1155/2015/364924 Text en Copyright © 2015 Andrea Matteucci et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Matteucci, Andrea
Varano, Monica
Mallozzi, Cinzia
Gaddini, Lucia
Villa, Marika
Gabrielli, Sara
Formisano, Giuseppe
Pricci, Flavia
Malchiodi-Albedi, Fiorella
Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview
title Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview
title_full Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview
title_fullStr Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview
title_full_unstemmed Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview
title_short Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview
title_sort primary retinal cultures as a tool for modeling diabetic retinopathy: an overview
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320900/
https://www.ncbi.nlm.nih.gov/pubmed/25688355
http://dx.doi.org/10.1155/2015/364924
work_keys_str_mv AT matteucciandrea primaryretinalculturesasatoolformodelingdiabeticretinopathyanoverview
AT varanomonica primaryretinalculturesasatoolformodelingdiabeticretinopathyanoverview
AT mallozzicinzia primaryretinalculturesasatoolformodelingdiabeticretinopathyanoverview
AT gaddinilucia primaryretinalculturesasatoolformodelingdiabeticretinopathyanoverview
AT villamarika primaryretinalculturesasatoolformodelingdiabeticretinopathyanoverview
AT gabriellisara primaryretinalculturesasatoolformodelingdiabeticretinopathyanoverview
AT formisanogiuseppe primaryretinalculturesasatoolformodelingdiabeticretinopathyanoverview
AT pricciflavia primaryretinalculturesasatoolformodelingdiabeticretinopathyanoverview
AT malchiodialbedifiorella primaryretinalculturesasatoolformodelingdiabeticretinopathyanoverview