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The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer

Lymph node metastasis (LNM) in gastric cancer is associated with higher rate of cancer recurrence and poor prognosis. As a result, a reliable biomarker for the prediction of LNM is important and would be valuable in the clinical practice. MiRNA microarray revealed that ten miRNAs were expressed sign...

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Autores principales: Huang, Kuo-Hung, Lan, Yuan-Tzu, Fang, Wen-Liang, Chen, Jen-Hao, Lo, Su-Shun, Li, Anna Fen-Yau, Chiou, Shih-Hwa, Wu, Chew-Wun, Shyr, Yi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320935/
https://www.ncbi.nlm.nih.gov/pubmed/25688358
http://dx.doi.org/10.1155/2015/543163
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author Huang, Kuo-Hung
Lan, Yuan-Tzu
Fang, Wen-Liang
Chen, Jen-Hao
Lo, Su-Shun
Li, Anna Fen-Yau
Chiou, Shih-Hwa
Wu, Chew-Wun
Shyr, Yi-Ming
author_facet Huang, Kuo-Hung
Lan, Yuan-Tzu
Fang, Wen-Liang
Chen, Jen-Hao
Lo, Su-Shun
Li, Anna Fen-Yau
Chiou, Shih-Hwa
Wu, Chew-Wun
Shyr, Yi-Ming
author_sort Huang, Kuo-Hung
collection PubMed
description Lymph node metastasis (LNM) in gastric cancer is associated with higher rate of cancer recurrence and poor prognosis. As a result, a reliable biomarker for the prediction of LNM is important and would be valuable in the clinical practice. MiRNA microarray revealed that ten miRNAs were expressed significantly different among patients with or without LNM. A total of 46 gastric cancer patients were enrolled and divided into two groups (23 in each group) according to the presence or absence of LNM. RT-PCR of these 10 miRNAs was investigated and compared between the two groups. MiR-1207-5p was significantly upregulated in gastric cancer patients without LNM compared with those with LNM. Patients with upregulated miR-1207-5p had less scirrhous stromal reaction, less lymphovascular invasion, and earlier pathological T category, N category, and TNM stage, compared with those with downregulated or unchanged miR-1207-5p. Multivariate analysis showed that stromal reaction type, lymphovascular invasion, pathological T category and TNM stage, and expression of miR-1207-5p were independent risk factors of LNM. MiR-1207-5p could serve as a useful biomarker in the prediction of LNM in gastric cancer.
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spelling pubmed-43209352015-02-16 The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer Huang, Kuo-Hung Lan, Yuan-Tzu Fang, Wen-Liang Chen, Jen-Hao Lo, Su-Shun Li, Anna Fen-Yau Chiou, Shih-Hwa Wu, Chew-Wun Shyr, Yi-Ming Biomed Res Int Research Article Lymph node metastasis (LNM) in gastric cancer is associated with higher rate of cancer recurrence and poor prognosis. As a result, a reliable biomarker for the prediction of LNM is important and would be valuable in the clinical practice. MiRNA microarray revealed that ten miRNAs were expressed significantly different among patients with or without LNM. A total of 46 gastric cancer patients were enrolled and divided into two groups (23 in each group) according to the presence or absence of LNM. RT-PCR of these 10 miRNAs was investigated and compared between the two groups. MiR-1207-5p was significantly upregulated in gastric cancer patients without LNM compared with those with LNM. Patients with upregulated miR-1207-5p had less scirrhous stromal reaction, less lymphovascular invasion, and earlier pathological T category, N category, and TNM stage, compared with those with downregulated or unchanged miR-1207-5p. Multivariate analysis showed that stromal reaction type, lymphovascular invasion, pathological T category and TNM stage, and expression of miR-1207-5p were independent risk factors of LNM. MiR-1207-5p could serve as a useful biomarker in the prediction of LNM in gastric cancer. Hindawi Publishing Corporation 2015 2015-01-22 /pmc/articles/PMC4320935/ /pubmed/25688358 http://dx.doi.org/10.1155/2015/543163 Text en Copyright © 2015 Kuo-Hung Huang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Huang, Kuo-Hung
Lan, Yuan-Tzu
Fang, Wen-Liang
Chen, Jen-Hao
Lo, Su-Shun
Li, Anna Fen-Yau
Chiou, Shih-Hwa
Wu, Chew-Wun
Shyr, Yi-Ming
The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer
title The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer
title_full The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer
title_fullStr The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer
title_full_unstemmed The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer
title_short The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer
title_sort correlation between mirna and lymph node metastasis in gastric cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320935/
https://www.ncbi.nlm.nih.gov/pubmed/25688358
http://dx.doi.org/10.1155/2015/543163
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