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The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer
Lymph node metastasis (LNM) in gastric cancer is associated with higher rate of cancer recurrence and poor prognosis. As a result, a reliable biomarker for the prediction of LNM is important and would be valuable in the clinical practice. MiRNA microarray revealed that ten miRNAs were expressed sign...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320935/ https://www.ncbi.nlm.nih.gov/pubmed/25688358 http://dx.doi.org/10.1155/2015/543163 |
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author | Huang, Kuo-Hung Lan, Yuan-Tzu Fang, Wen-Liang Chen, Jen-Hao Lo, Su-Shun Li, Anna Fen-Yau Chiou, Shih-Hwa Wu, Chew-Wun Shyr, Yi-Ming |
author_facet | Huang, Kuo-Hung Lan, Yuan-Tzu Fang, Wen-Liang Chen, Jen-Hao Lo, Su-Shun Li, Anna Fen-Yau Chiou, Shih-Hwa Wu, Chew-Wun Shyr, Yi-Ming |
author_sort | Huang, Kuo-Hung |
collection | PubMed |
description | Lymph node metastasis (LNM) in gastric cancer is associated with higher rate of cancer recurrence and poor prognosis. As a result, a reliable biomarker for the prediction of LNM is important and would be valuable in the clinical practice. MiRNA microarray revealed that ten miRNAs were expressed significantly different among patients with or without LNM. A total of 46 gastric cancer patients were enrolled and divided into two groups (23 in each group) according to the presence or absence of LNM. RT-PCR of these 10 miRNAs was investigated and compared between the two groups. MiR-1207-5p was significantly upregulated in gastric cancer patients without LNM compared with those with LNM. Patients with upregulated miR-1207-5p had less scirrhous stromal reaction, less lymphovascular invasion, and earlier pathological T category, N category, and TNM stage, compared with those with downregulated or unchanged miR-1207-5p. Multivariate analysis showed that stromal reaction type, lymphovascular invasion, pathological T category and TNM stage, and expression of miR-1207-5p were independent risk factors of LNM. MiR-1207-5p could serve as a useful biomarker in the prediction of LNM in gastric cancer. |
format | Online Article Text |
id | pubmed-4320935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43209352015-02-16 The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer Huang, Kuo-Hung Lan, Yuan-Tzu Fang, Wen-Liang Chen, Jen-Hao Lo, Su-Shun Li, Anna Fen-Yau Chiou, Shih-Hwa Wu, Chew-Wun Shyr, Yi-Ming Biomed Res Int Research Article Lymph node metastasis (LNM) in gastric cancer is associated with higher rate of cancer recurrence and poor prognosis. As a result, a reliable biomarker for the prediction of LNM is important and would be valuable in the clinical practice. MiRNA microarray revealed that ten miRNAs were expressed significantly different among patients with or without LNM. A total of 46 gastric cancer patients were enrolled and divided into two groups (23 in each group) according to the presence or absence of LNM. RT-PCR of these 10 miRNAs was investigated and compared between the two groups. MiR-1207-5p was significantly upregulated in gastric cancer patients without LNM compared with those with LNM. Patients with upregulated miR-1207-5p had less scirrhous stromal reaction, less lymphovascular invasion, and earlier pathological T category, N category, and TNM stage, compared with those with downregulated or unchanged miR-1207-5p. Multivariate analysis showed that stromal reaction type, lymphovascular invasion, pathological T category and TNM stage, and expression of miR-1207-5p were independent risk factors of LNM. MiR-1207-5p could serve as a useful biomarker in the prediction of LNM in gastric cancer. Hindawi Publishing Corporation 2015 2015-01-22 /pmc/articles/PMC4320935/ /pubmed/25688358 http://dx.doi.org/10.1155/2015/543163 Text en Copyright © 2015 Kuo-Hung Huang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Huang, Kuo-Hung Lan, Yuan-Tzu Fang, Wen-Liang Chen, Jen-Hao Lo, Su-Shun Li, Anna Fen-Yau Chiou, Shih-Hwa Wu, Chew-Wun Shyr, Yi-Ming The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer |
title | The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer |
title_full | The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer |
title_fullStr | The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer |
title_full_unstemmed | The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer |
title_short | The Correlation between miRNA and Lymph Node Metastasis in Gastric Cancer |
title_sort | correlation between mirna and lymph node metastasis in gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320935/ https://www.ncbi.nlm.nih.gov/pubmed/25688358 http://dx.doi.org/10.1155/2015/543163 |
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