A Rapid One-Generation Genetic Screen in a Drosophila Model to Capture Rhabdomyosarcoma Effectors and Therapeutic Targets

Rhabdomyosarcoma (RMS) is an aggressive childhood malignancy of neoplastic muscle-lineage precursors that fail to terminally differentiate into syncytial muscle. The most aggressive form of RMS, alveolar-RMS, is driven by misexpression of the PAX-FOXO1 oncoprotein, which is generated by recurrent ch...

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Detalles Bibliográficos
Autores principales: Galindo, Kathleen A., Endicott, Tiana R., Avirneni-Vadlamudi, Usha, Galindo, Rene L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2014
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321029/
https://www.ncbi.nlm.nih.gov/pubmed/25491943
http://dx.doi.org/10.1534/g3.114.015818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321029/
https://www.ncbi.nlm.nih.gov/pubmed/25491943
http://dx.doi.org/10.1534/g3.114.015818

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