A preliminary exploration on DNA methylation of transgene across generations in transgenic rats

Epigenetic heritability is an important issue in the field of genetics and also in the development of many human diseases. In this study, we created a transgenic rat model and investigated the transgenerational methylation patterns in these animals. The transgene DNA fragment was unmethylated before...

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Detalles Bibliográficos
Autores principales: Li, Qiling, Xu, Wei, Cui, Ye, Ma, Li, Richards, Jendai, Li, Wenzhi, Ma, Yamin, Fu, Guoxing, Bythwood, Tameka, Wang, Yueling, Li, Xu, Song, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321119/
https://www.ncbi.nlm.nih.gov/pubmed/25659774
http://dx.doi.org/10.1038/srep08292

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