Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates

We report the microbiological characterization of four New Delhi metallo-β-lactamase-1 (bla (NDM-1))-producing Enterobacteriaceae isolated in Rio de Janeiro, Brazil. bla (NDM-1) was located on a conjugative plasmid and was associated with Klebsiella pneumoniae carbapenemase-2 (bla (KPC-2)) or aminog...

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Autores principales: Quiles, M.G., Rocchetti, T.T., Fehlberg, L.C., Kusano, E.J.U., Chebabo, A., Pereira, R.M.G., Gales, A.C., Pignatari, A.C.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2014
Materias:
Clinical Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321224/
https://www.ncbi.nlm.nih.gov/pubmed/25466163
http://dx.doi.org/10.1590/1414-431X20144154
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author Quiles, M.G.
Rocchetti, T.T.
Fehlberg, L.C.
Kusano, E.J.U.
Chebabo, A.
Pereira, R.M.G.
Gales, A.C.
Pignatari, A.C.C.
author_facet Quiles, M.G.
Rocchetti, T.T.
Fehlberg, L.C.
Kusano, E.J.U.
Chebabo, A.
Pereira, R.M.G.
Gales, A.C.
Pignatari, A.C.C.
author_sort Quiles, M.G.
collection PubMed
description We report the microbiological characterization of four New Delhi metallo-β-lactamase-1 (bla (NDM-1))-producing Enterobacteriaceae isolated in Rio de Janeiro, Brazil. bla (NDM-1) was located on a conjugative plasmid and was associated with Klebsiella pneumoniae carbapenemase-2 (bla (KPC-2)) or aminoglycoside-resistance methylase (armA), a 16S rRNA methylase not previously reported in Brazil, in two distinct strains of Enterobacter cloacae. Our results suggested that the introduction of bla (NDM-1) in Brazil has been accompanied by rapid spread, since our isolates showed no genetic relationship.
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spelling pubmed-43212242015-02-24 Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates Quiles, M.G. Rocchetti, T.T. Fehlberg, L.C. Kusano, E.J.U. Chebabo, A. Pereira, R.M.G. Gales, A.C. Pignatari, A.C.C. Braz J Med Biol Res Clinical Investigation We report the microbiological characterization of four New Delhi metallo-β-lactamase-1 (bla (NDM-1))-producing Enterobacteriaceae isolated in Rio de Janeiro, Brazil. bla (NDM-1) was located on a conjugative plasmid and was associated with Klebsiella pneumoniae carbapenemase-2 (bla (KPC-2)) or aminoglycoside-resistance methylase (armA), a 16S rRNA methylase not previously reported in Brazil, in two distinct strains of Enterobacter cloacae. Our results suggested that the introduction of bla (NDM-1) in Brazil has been accompanied by rapid spread, since our isolates showed no genetic relationship. Associação Brasileira de Divulgação Científica 2014-12-05 /pmc/articles/PMC4321224/ /pubmed/25466163 http://dx.doi.org/10.1590/1414-431X20144154 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigation
Quiles, M.G.
Rocchetti, T.T.
Fehlberg, L.C.
Kusano, E.J.U.
Chebabo, A.
Pereira, R.M.G.
Gales, A.C.
Pignatari, A.C.C.
Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates
title Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates
title_full Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates
title_fullStr Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates
title_full_unstemmed Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates
title_short Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates
title_sort unusual association of ndm-1 with kpc-2 and arma among brazilian enterobacteriaceae isolates
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321224/
https://www.ncbi.nlm.nih.gov/pubmed/25466163
http://dx.doi.org/10.1590/1414-431X20144154
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