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Relationships of Urinary VEGF/CR and IL-6/CR with Glomerular Pathological Injury in Asymptomatic Hematuria Patients

BACKGROUND: Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) have important functions in injury and repair processes of glomerular intrinsic cells. A study was conducted to analyze the urinary VEGF/creatinine (CR) and IL-6/CR levels in simple hematuria patients after excluding the...

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Autores principales: Ma, Lu, Gao, Yinghe, Chen, Guanglei, Gong, Junhua, Yang, Dan, Xie, Yongxin, Wang, Mingcui, Chen, Hong, Song, Minghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321409/
https://www.ncbi.nlm.nih.gov/pubmed/25634015
http://dx.doi.org/10.12659/MSM.892085
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author Ma, Lu
Gao, Yinghe
Chen, Guanglei
Gong, Junhua
Yang, Dan
Xie, Yongxin
Wang, Mingcui
Chen, Hong
Song, Minghui
author_facet Ma, Lu
Gao, Yinghe
Chen, Guanglei
Gong, Junhua
Yang, Dan
Xie, Yongxin
Wang, Mingcui
Chen, Hong
Song, Minghui
author_sort Ma, Lu
collection PubMed
description BACKGROUND: Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) have important functions in injury and repair processes of glomerular intrinsic cells. A study was conducted to analyze the urinary VEGF/creatinine (CR) and IL-6/CR levels in simple hematuria patients after excluding the interference of creatinine. We aimed to investigate the function and relationships of the above indices in the glomerular pathological injury process, and to elaborate the values of urinary VEGF and IL-6 changes in the diagnosis of asymptomatic hematuria or hematuria with proteinuria. MATERIAL/METHODS: A total of 121 renal hematuria patients diagnosed by clinical and laboratory tests were included as research subjects. The midstream fresh morning urine was collected on the day renal biopsy was performed. RESULTS: The IL-6/CR value of the group III was significantly greater than in group I (Z=−2.478, P<0.05), with a statistically significant difference between these 2 groups. The VEGF/CR value of group III was significantly greater than in group II (P<0.01). Compared with group I, the VEGF/CR of group III was significantly greater (Z=−4.65, P<0.01), with a statistically significant difference. CONCLUSIONS: The VEGF/CR and IL-6/CR values in simple hematuria patients were positively correlated with glomerular pathological injury scores. VEGF/CR and IL-6/CR might be used as biological diagnostic indicators in determining the extent of simple hematuria glomerular injury.
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spelling pubmed-43214092015-02-13 Relationships of Urinary VEGF/CR and IL-6/CR with Glomerular Pathological Injury in Asymptomatic Hematuria Patients Ma, Lu Gao, Yinghe Chen, Guanglei Gong, Junhua Yang, Dan Xie, Yongxin Wang, Mingcui Chen, Hong Song, Minghui Med Sci Monit Clinical Research BACKGROUND: Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) have important functions in injury and repair processes of glomerular intrinsic cells. A study was conducted to analyze the urinary VEGF/creatinine (CR) and IL-6/CR levels in simple hematuria patients after excluding the interference of creatinine. We aimed to investigate the function and relationships of the above indices in the glomerular pathological injury process, and to elaborate the values of urinary VEGF and IL-6 changes in the diagnosis of asymptomatic hematuria or hematuria with proteinuria. MATERIAL/METHODS: A total of 121 renal hematuria patients diagnosed by clinical and laboratory tests were included as research subjects. The midstream fresh morning urine was collected on the day renal biopsy was performed. RESULTS: The IL-6/CR value of the group III was significantly greater than in group I (Z=−2.478, P<0.05), with a statistically significant difference between these 2 groups. The VEGF/CR value of group III was significantly greater than in group II (P<0.01). Compared with group I, the VEGF/CR of group III was significantly greater (Z=−4.65, P<0.01), with a statistically significant difference. CONCLUSIONS: The VEGF/CR and IL-6/CR values in simple hematuria patients were positively correlated with glomerular pathological injury scores. VEGF/CR and IL-6/CR might be used as biological diagnostic indicators in determining the extent of simple hematuria glomerular injury. International Scientific Literature, Inc. 2015-01-30 /pmc/articles/PMC4321409/ /pubmed/25634015 http://dx.doi.org/10.12659/MSM.892085 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Clinical Research
Ma, Lu
Gao, Yinghe
Chen, Guanglei
Gong, Junhua
Yang, Dan
Xie, Yongxin
Wang, Mingcui
Chen, Hong
Song, Minghui
Relationships of Urinary VEGF/CR and IL-6/CR with Glomerular Pathological Injury in Asymptomatic Hematuria Patients
title Relationships of Urinary VEGF/CR and IL-6/CR with Glomerular Pathological Injury in Asymptomatic Hematuria Patients
title_full Relationships of Urinary VEGF/CR and IL-6/CR with Glomerular Pathological Injury in Asymptomatic Hematuria Patients
title_fullStr Relationships of Urinary VEGF/CR and IL-6/CR with Glomerular Pathological Injury in Asymptomatic Hematuria Patients
title_full_unstemmed Relationships of Urinary VEGF/CR and IL-6/CR with Glomerular Pathological Injury in Asymptomatic Hematuria Patients
title_short Relationships of Urinary VEGF/CR and IL-6/CR with Glomerular Pathological Injury in Asymptomatic Hematuria Patients
title_sort relationships of urinary vegf/cr and il-6/cr with glomerular pathological injury in asymptomatic hematuria patients
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321409/
https://www.ncbi.nlm.nih.gov/pubmed/25634015
http://dx.doi.org/10.12659/MSM.892085
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