Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior

Hutchinson–Gilford progeria syndrome (HGPS) is a segmental progeroid syndrome with multiple features suggestive of premature accelerated aging. Accumulation of progerin is thought to underlie the pathophysiology of HGPS. However, despite ubiquitous expression of lamin A in all differentiated cells,...

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Detalles Bibliográficos
Autores principales: Baek, Jean-Ha, Schmidt, Eva, Viceconte, Nikenza, Strandgren, Charlotte, Pernold, Karin, Richard, Thibaud J. C., Van Leeuwen, Fred W., Dantuma, Nico P., Damberg, Peter, Hultenby, Kjell, Ulfhake, Brun, Mugnaini, Enrico, Rozell, Björn, Eriksson, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321440/
https://www.ncbi.nlm.nih.gov/pubmed/25343989
http://dx.doi.org/10.1093/hmg/ddu541

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