Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes

Initial results from sequencing studies suggest that there are relatively few low-frequency (<5%) variants associated with large effects on common phenotypes. We performed low-pass whole-genome sequencing in 680 individuals from the InCHIANTI study to test two primary hypotheses: (i) that sequenc...

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Detalles Bibliográficos
Autores principales: Wood, Andrew R., Tuke, Marcus A., Nalls, Mike, Hernandez, Dena, Gibbs, J. Raphael, Lin, Haoxiang, Xu, Christopher S., Li, Qibin, Shen, Juan, Jun, Goo, Almeida, Marcio, Tanaka, Toshiko, Perry, John R. B., Gaulton, Kyle, Rivas, Manny, Pearson, Richard, Curran, Joanne E., Johnson, Matthew P., Göring, Harald H. H., Duggirala, Ravindranath, Blangero, John, Mccarthy, Mark I., Bandinelli, Stefania, Murray, Anna, Weedon, Michael N., Singleton, Andrew, Melzer, David, Ferrucci, Luigi, Frayling, Timothy M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Association Studies Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321449/
https://www.ncbi.nlm.nih.gov/pubmed/25378555
http://dx.doi.org/10.1093/hmg/ddu560

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