Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IκBα

Patients with ectodermal dysplasia with immunodeficiency (ED-ID) caused by mutations in the inhibitor of NF-κB α (IκBα) are susceptible to severe recurrent infections, despite normal T and B cell numbers and intact in vitro lymphocyte function. Moreover, the outcome of hematopoietic stem cell transp...

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Detalles Bibliográficos
Autores principales: Mooster, Jana L., Le Bras, Severine, Massaad, Michel J., Jabara, Haifa, Yoon, Juhan, Galand, Claire, Heesters, Balthasar A., Burton, Oliver T., Mattoo, Hamid, Manis, John, Geha, Raif S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322042/
https://www.ncbi.nlm.nih.gov/pubmed/25601653
http://dx.doi.org/10.1084/jem.20140979

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