Cargando…

Early-Stage Treatment with Withaferin A Reduces Levels of Misfolded Superoxide Dismutase 1 and Extends Lifespan in a Mouse Model of Amyotrophic Lateral Sclerosis

Approximately 20 % of cases of familial amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). Recent studies have shown that Withaferin A (WA), an inhibitor of nuclear factor-kappa B activity, was efficient in reducing disease phenotype i...

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Priyanka, Julien, Jean-Pierre, Kriz, Jasna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322065/
https://www.ncbi.nlm.nih.gov/pubmed/25404049
http://dx.doi.org/10.1007/s13311-014-0311-0

Ejemplares similares