A Ligand-observed Mass Spectrometry Approach Integrated into the Fragment Based Lead Discovery Pipeline

In fragment-based lead discovery (FBLD), a cascade combining multiple orthogonal technologies is required for reliable detection and characterization of fragment binding to the target. Given the limitations of the mainstream screening techniques, we presented a ligand-observed mass spectrometry appr...

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Detalles Bibliográficos
Autores principales: Chen, Xin, Qin, Shanshan, Chen, Shuai, Li, Jinlong, Li, Lixin, Wang, Zhongling, Wang, Quan, Lin, Jianping, Yang, Cheng, Shui, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322365/
https://www.ncbi.nlm.nih.gov/pubmed/25666181
http://dx.doi.org/10.1038/srep08361

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