Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate

BACKGROUND: Cell growth requires fatty acids for membrane synthesis. Fatty acids are assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen replete conditions, acetyl-CoA is predominantly derived from glucose. In hypoxia, however, flux from glucose to acetyl-CoA decr...

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Detalles Bibliográficos
Autores principales: Kamphorst, Jurre J, Chung, Michelle K, Fan, Jing, Rabinowitz, Joshua D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322440/
https://www.ncbi.nlm.nih.gov/pubmed/25671109
http://dx.doi.org/10.1186/2049-3002-2-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322440/
https://www.ncbi.nlm.nih.gov/pubmed/25671109
http://dx.doi.org/10.1186/2049-3002-2-23

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