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Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate
BACKGROUND: Cell growth requires fatty acids for membrane synthesis. Fatty acids are assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen replete conditions, acetyl-CoA is predominantly derived from glucose. In hypoxia, however, flux from glucose to acetyl-CoA decr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322440/ https://www.ncbi.nlm.nih.gov/pubmed/25671109 http://dx.doi.org/10.1186/2049-3002-2-23 |