Enantioselective Total Synthesis of (−)-Nardoaristolone B via a Gold(I)-Catalyzed Oxidative Cyclization

[Image: see text] The first enantioselective total synthesis of (−)-nardoaristolone B is accomplished by the implementation of an enantio- and diastereoselective copper(I)-catalyzed conjugate addition/enolate trapping sequence and a gold(I)-catalyzed oxidative cyclization (intermolecular oxidant), e...

Descripción completa

Detalles Bibliográficos
Autores principales: Homs, Anna, Muratore, Michael E., Echavarren, Antonio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322447/
https://www.ncbi.nlm.nih.gov/pubmed/25563976
http://dx.doi.org/10.1021/ol503531n
_version_ 1782356382123556864
author Homs, Anna
Muratore, Michael E.
Echavarren, Antonio M.
author_facet Homs, Anna
Muratore, Michael E.
Echavarren, Antonio M.
author_sort Homs, Anna
collection PubMed
description [Image: see text] The first enantioselective total synthesis of (−)-nardoaristolone B is accomplished by the implementation of an enantio- and diastereoselective copper(I)-catalyzed conjugate addition/enolate trapping sequence and a gold(I)-catalyzed oxidative cyclization (intermolecular oxidant), employed for the first time in total synthesis.
format Online
Article
Text
id pubmed-4322447
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-43224472015-02-14 Enantioselective Total Synthesis of (−)-Nardoaristolone B via a Gold(I)-Catalyzed Oxidative Cyclization Homs, Anna Muratore, Michael E. Echavarren, Antonio M. Org Lett [Image: see text] The first enantioselective total synthesis of (−)-nardoaristolone B is accomplished by the implementation of an enantio- and diastereoselective copper(I)-catalyzed conjugate addition/enolate trapping sequence and a gold(I)-catalyzed oxidative cyclization (intermolecular oxidant), employed for the first time in total synthesis. American Chemical Society 2015-01-07 2015-02-06 /pmc/articles/PMC4322447/ /pubmed/25563976 http://dx.doi.org/10.1021/ol503531n Text en Copyright © 2015 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Homs, Anna
Muratore, Michael E.
Echavarren, Antonio M.
Enantioselective Total Synthesis of (−)-Nardoaristolone B via a Gold(I)-Catalyzed Oxidative Cyclization
title Enantioselective Total Synthesis of (−)-Nardoaristolone B via a Gold(I)-Catalyzed Oxidative Cyclization
title_full Enantioselective Total Synthesis of (−)-Nardoaristolone B via a Gold(I)-Catalyzed Oxidative Cyclization
title_fullStr Enantioselective Total Synthesis of (−)-Nardoaristolone B via a Gold(I)-Catalyzed Oxidative Cyclization
title_full_unstemmed Enantioselective Total Synthesis of (−)-Nardoaristolone B via a Gold(I)-Catalyzed Oxidative Cyclization
title_short Enantioselective Total Synthesis of (−)-Nardoaristolone B via a Gold(I)-Catalyzed Oxidative Cyclization
title_sort enantioselective total synthesis of (−)-nardoaristolone b via a gold(i)-catalyzed oxidative cyclization
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322447/
https://www.ncbi.nlm.nih.gov/pubmed/25563976
http://dx.doi.org/10.1021/ol503531n
work_keys_str_mv AT homsanna enantioselectivetotalsynthesisofnardoaristolonebviaagoldicatalyzedoxidativecyclization
AT muratoremichaele enantioselectivetotalsynthesisofnardoaristolonebviaagoldicatalyzedoxidativecyclization
AT echavarrenantoniom enantioselectivetotalsynthesisofnardoaristolonebviaagoldicatalyzedoxidativecyclization

Ejemplares similares