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Viruses in cancer cell plasticity: the role of hepatitis C virus in hepatocellular carcinoma
Viruses are considered as causative agents of a significant proportion of human cancers. While the very stringent criteria used for their classification probably lead to an underestimation, only six human viruses are currently classified as oncogenic. In this review we give a brief historical accoun...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322526/ https://www.ncbi.nlm.nih.gov/pubmed/25691824 http://dx.doi.org/10.5114/wo.2014.47132 |
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author | Hibner, Urszula Grégoire, Damien |
author_facet | Hibner, Urszula Grégoire, Damien |
author_sort | Hibner, Urszula |
collection | PubMed |
description | Viruses are considered as causative agents of a significant proportion of human cancers. While the very stringent criteria used for their classification probably lead to an underestimation, only six human viruses are currently classified as oncogenic. In this review we give a brief historical account of the discovery of oncogenic viruses and then analyse the mechanisms underlying the infectious causes of cancer. We discuss viral strategies that evolved to ensure virus propagation and spread can alter cellular homeostasis in a way that increases the probability of oncogenic transformation and acquisition of stem cell phenotype. We argue that a useful way of analysing the convergent characteristics of viral infection and cancer is to examine how viruses affect the so-called cancer hallmarks. This view of infectious origin of cancer is illustrated by examples from hepatitis C infection, which is associated with a high proportion of hepatocellular carcinoma. |
format | Online Article Text |
id | pubmed-4322526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-43225262015-02-17 Viruses in cancer cell plasticity: the role of hepatitis C virus in hepatocellular carcinoma Hibner, Urszula Grégoire, Damien Contemp Oncol (Pozn) Review Viruses are considered as causative agents of a significant proportion of human cancers. While the very stringent criteria used for their classification probably lead to an underestimation, only six human viruses are currently classified as oncogenic. In this review we give a brief historical account of the discovery of oncogenic viruses and then analyse the mechanisms underlying the infectious causes of cancer. We discuss viral strategies that evolved to ensure virus propagation and spread can alter cellular homeostasis in a way that increases the probability of oncogenic transformation and acquisition of stem cell phenotype. We argue that a useful way of analysing the convergent characteristics of viral infection and cancer is to examine how viruses affect the so-called cancer hallmarks. This view of infectious origin of cancer is illustrated by examples from hepatitis C infection, which is associated with a high proportion of hepatocellular carcinoma. Termedia Publishing House 2015-01-20 2015 /pmc/articles/PMC4322526/ /pubmed/25691824 http://dx.doi.org/10.5114/wo.2014.47132 Text en Copyright © 2015 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Hibner, Urszula Grégoire, Damien Viruses in cancer cell plasticity: the role of hepatitis C virus in hepatocellular carcinoma |
title | Viruses in cancer cell plasticity: the role of hepatitis C virus in hepatocellular carcinoma |
title_full | Viruses in cancer cell plasticity: the role of hepatitis C virus in hepatocellular carcinoma |
title_fullStr | Viruses in cancer cell plasticity: the role of hepatitis C virus in hepatocellular carcinoma |
title_full_unstemmed | Viruses in cancer cell plasticity: the role of hepatitis C virus in hepatocellular carcinoma |
title_short | Viruses in cancer cell plasticity: the role of hepatitis C virus in hepatocellular carcinoma |
title_sort | viruses in cancer cell plasticity: the role of hepatitis c virus in hepatocellular carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322526/ https://www.ncbi.nlm.nih.gov/pubmed/25691824 http://dx.doi.org/10.5114/wo.2014.47132 |
work_keys_str_mv | AT hibnerurszula virusesincancercellplasticitytheroleofhepatitiscvirusinhepatocellularcarcinoma AT gregoiredamien virusesincancercellplasticitytheroleofhepatitiscvirusinhepatocellularcarcinoma |