Biology of renal tumour cancer stem cells applied in medicine

The present article highlights the diverse role of stem cells in normal kidney and renal cancer, with special emphasis on surface markers. Proteins such as CD105 and CD133 have been reported as being significant in clear cell renal cell carcinoma (ccRCC) cancer stem cells. The role of normal kidney...

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Detalles Bibliográficos
Autores principales: Matak, Damian, Szymanski, Lukasz, Szczylik, Cezary, Sledziewski, Rafal, Lian, Fei, Bartnik, Ewa, Sobocinska, Anna, Czarnecka, Anna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322535/
https://www.ncbi.nlm.nih.gov/pubmed/25691821
http://dx.doi.org/10.5114/wo.2014.47128
Descripción
Sumario:The present article highlights the diverse role of stem cells in normal kidney and renal cancer, with special emphasis on surface markers. Proteins such as CD105 and CD133 have been reported as being significant in clear cell renal cell carcinoma (ccRCC) cancer stem cells. The role of normal kidney progenitor cells and their surface markers is compared with the role of those surface markers in ccRCC. Subsequently, we state the current hypothesis about origin of tumour-initiating cells along with their clinical and prognostic potential in RCC. Finally, we present future perspectives with respect to recent studies.

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