Biology of renal tumour cancer stem cells applied in medicine

The present article highlights the diverse role of stem cells in normal kidney and renal cancer, with special emphasis on surface markers. Proteins such as CD105 and CD133 have been reported as being significant in clear cell renal cell carcinoma (ccRCC) cancer stem cells. The role of normal kidney...

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Autores principales: Matak, Damian, Szymanski, Lukasz, Szczylik, Cezary, Sledziewski, Rafal, Lian, Fei, Bartnik, Ewa, Sobocinska, Anna, Czarnecka, Anna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322535/
https://www.ncbi.nlm.nih.gov/pubmed/25691821
http://dx.doi.org/10.5114/wo.2014.47128
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author Matak, Damian
Szymanski, Lukasz
Szczylik, Cezary
Sledziewski, Rafal
Lian, Fei
Bartnik, Ewa
Sobocinska, Anna
Czarnecka, Anna M.
author_facet Matak, Damian
Szymanski, Lukasz
Szczylik, Cezary
Sledziewski, Rafal
Lian, Fei
Bartnik, Ewa
Sobocinska, Anna
Czarnecka, Anna M.
author_sort Matak, Damian
collection PubMed
description The present article highlights the diverse role of stem cells in normal kidney and renal cancer, with special emphasis on surface markers. Proteins such as CD105 and CD133 have been reported as being significant in clear cell renal cell carcinoma (ccRCC) cancer stem cells. The role of normal kidney progenitor cells and their surface markers is compared with the role of those surface markers in ccRCC. Subsequently, we state the current hypothesis about origin of tumour-initiating cells along with their clinical and prognostic potential in RCC. Finally, we present future perspectives with respect to recent studies.
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spelling pubmed-43225352015-02-17 Biology of renal tumour cancer stem cells applied in medicine Matak, Damian Szymanski, Lukasz Szczylik, Cezary Sledziewski, Rafal Lian, Fei Bartnik, Ewa Sobocinska, Anna Czarnecka, Anna M. Contemp Oncol (Pozn) Review The present article highlights the diverse role of stem cells in normal kidney and renal cancer, with special emphasis on surface markers. Proteins such as CD105 and CD133 have been reported as being significant in clear cell renal cell carcinoma (ccRCC) cancer stem cells. The role of normal kidney progenitor cells and their surface markers is compared with the role of those surface markers in ccRCC. Subsequently, we state the current hypothesis about origin of tumour-initiating cells along with their clinical and prognostic potential in RCC. Finally, we present future perspectives with respect to recent studies. Termedia Publishing House 2015-01-20 2015 /pmc/articles/PMC4322535/ /pubmed/25691821 http://dx.doi.org/10.5114/wo.2014.47128 Text en Copyright © 2015 Termedia http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Matak, Damian
Szymanski, Lukasz
Szczylik, Cezary
Sledziewski, Rafal
Lian, Fei
Bartnik, Ewa
Sobocinska, Anna
Czarnecka, Anna M.
Biology of renal tumour cancer stem cells applied in medicine
title Biology of renal tumour cancer stem cells applied in medicine
title_full Biology of renal tumour cancer stem cells applied in medicine
title_fullStr Biology of renal tumour cancer stem cells applied in medicine
title_full_unstemmed Biology of renal tumour cancer stem cells applied in medicine
title_short Biology of renal tumour cancer stem cells applied in medicine
title_sort biology of renal tumour cancer stem cells applied in medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322535/
https://www.ncbi.nlm.nih.gov/pubmed/25691821
http://dx.doi.org/10.5114/wo.2014.47128
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