Retroperitoneal Liposarcoma: Current Insights in Diagnosis and Treatment

Retroperitoneal liposarcoma (RLS) is a rare, biologically heterogeneous tumor that present considerable challenges due to its size and deep location. As a consequence, the majority of patients with high-grade RLS will develop locally recurrent disease following surgery, and this constitutes the caus...

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Detalles Bibliográficos
Autores principales: Matthyssens, Lucas E., Creytens, David, Ceelen, Wim P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322543/
https://www.ncbi.nlm.nih.gov/pubmed/25713799
http://dx.doi.org/10.3389/fsurg.2015.00004
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author Matthyssens, Lucas E.
Creytens, David
Ceelen, Wim P.
author_facet Matthyssens, Lucas E.
Creytens, David
Ceelen, Wim P.
author_sort Matthyssens, Lucas E.
collection PubMed
description Retroperitoneal liposarcoma (RLS) is a rare, biologically heterogeneous tumor that present considerable challenges due to its size and deep location. As a consequence, the majority of patients with high-grade RLS will develop locally recurrent disease following surgery, and this constitutes the cause of death in most patients. Here, we review current insights and controversies regarding histology, molecular biology, extent of surgery, (neo)adjuvant treatment, and systemic treatment including novel targeted agents in RLS.
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spelling pubmed-43225432015-02-24 Retroperitoneal Liposarcoma: Current Insights in Diagnosis and Treatment Matthyssens, Lucas E. Creytens, David Ceelen, Wim P. Front Surg Surgery Retroperitoneal liposarcoma (RLS) is a rare, biologically heterogeneous tumor that present considerable challenges due to its size and deep location. As a consequence, the majority of patients with high-grade RLS will develop locally recurrent disease following surgery, and this constitutes the cause of death in most patients. Here, we review current insights and controversies regarding histology, molecular biology, extent of surgery, (neo)adjuvant treatment, and systemic treatment including novel targeted agents in RLS. Frontiers Media S.A. 2015-02-10 /pmc/articles/PMC4322543/ /pubmed/25713799 http://dx.doi.org/10.3389/fsurg.2015.00004 Text en Copyright © 2015 Matthyssens, Creytens and Ceelen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Matthyssens, Lucas E.
Creytens, David
Ceelen, Wim P.
Retroperitoneal Liposarcoma: Current Insights in Diagnosis and Treatment
title Retroperitoneal Liposarcoma: Current Insights in Diagnosis and Treatment
title_full Retroperitoneal Liposarcoma: Current Insights in Diagnosis and Treatment
title_fullStr Retroperitoneal Liposarcoma: Current Insights in Diagnosis and Treatment
title_full_unstemmed Retroperitoneal Liposarcoma: Current Insights in Diagnosis and Treatment
title_short Retroperitoneal Liposarcoma: Current Insights in Diagnosis and Treatment
title_sort retroperitoneal liposarcoma: current insights in diagnosis and treatment
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322543/
https://www.ncbi.nlm.nih.gov/pubmed/25713799
http://dx.doi.org/10.3389/fsurg.2015.00004
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AT creytensdavid retroperitonealliposarcomacurrentinsightsindiagnosisandtreatment
AT ceelenwimp retroperitonealliposarcomacurrentinsightsindiagnosisandtreatment

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