Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

BACKGROUND: Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle. SDH mutations resulting in enzymatic dysfunction have been found to be a predisposing factor in various hereditary cancers. Therefore, SDH ha...

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Detalles Bibliográficos
Autores principales: Aspuria, Paul-Joseph P, Lunt, Sophia Y, Väremo, Leif, Vergnes, Laurent, Gozo, Maricel, Beach, Jessica A, Salumbides, Brenda, Reue, Karen, Wiedemeyer, W Ruprecht, Nielsen, Jens, Karlan, Beth Y, Orsulic, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322794/
https://www.ncbi.nlm.nih.gov/pubmed/25671108
http://dx.doi.org/10.1186/2049-3002-2-21

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