Deficits in Endogenous Adenosine Formation by Ecto-5′-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis

AMP dephosphorylation via ecto-5′-nucleotidase/CD73 is the rate limiting step to generate extracellular adenosine (ADO) from released adenine nucleotides. ADO, via A(2A) receptors (A(2A)Rs), is a potent modulator of neuromuscular and immunological responses. The pivotal role of ecto-5′-nucleotidase/...

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Detalles Bibliográficos
Autores principales: Oliveira, Laura, Correia, Alexandra, Cristina Costa, Ana, Guerra-Gomes, Sónia, Ferreirinha, Fátima, Magalhães-Cardoso, Maria Teresa, Vilanova, Manuel, Correia-de-Sá, Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322825/
https://www.ncbi.nlm.nih.gov/pubmed/25691808
http://dx.doi.org/10.1155/2015/460610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322825/
https://www.ncbi.nlm.nih.gov/pubmed/25691808
http://dx.doi.org/10.1155/2015/460610

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