Disposition of linezolid or daptomycin in Enterococcal bloodstream infections according to vancomycin resistant Enterococcus colonization

Vancomycin resistant Enterococcus (VRE) colonized patients are likely to receive VRE targeted Gram-positive antibiotics and may not be de-escalated appropriately once final cultures are available. A retrospective cohort study was conducted in VRE-colonized and non-VRE colonized patients with Enteroc...

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Autores principales: Short, Elizabeth, Esterly, John, Postelnick, Michael, Ong, Jeannie, McLaughlin, Milena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322851/
https://www.ncbi.nlm.nih.gov/pubmed/25671098
http://dx.doi.org/10.1186/2047-2994-3-37
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author Short, Elizabeth
Esterly, John
Postelnick, Michael
Ong, Jeannie
McLaughlin, Milena
author_facet Short, Elizabeth
Esterly, John
Postelnick, Michael
Ong, Jeannie
McLaughlin, Milena
author_sort Short, Elizabeth
collection PubMed
description Vancomycin resistant Enterococcus (VRE) colonized patients are likely to receive VRE targeted Gram-positive antibiotics and may not be de-escalated appropriately once final cultures are available. A retrospective cohort study was conducted in VRE-colonized and non-VRE colonized patients with Enterococcal bloodstream infections. Of 101 patients (n = 50 VRE-colonized; n = 51 non-colonized), empiric therapy with linezolid or daptomycin was started more often in VRE-colonized than non-colonized patients (n = 8, 15.5% vs n = 27, 54%, p < 0.01). There was no difference in de-escalation once VRE infection was ruled out (non-colonized, n = 2, 66.7% vs VRE-colonized, n = 2, 50%, p = 0.09). This study encourages continued stewardship vigilance to decrease inappropriate antibiotic use.
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spelling pubmed-43228512015-02-11 Disposition of linezolid or daptomycin in Enterococcal bloodstream infections according to vancomycin resistant Enterococcus colonization Short, Elizabeth Esterly, John Postelnick, Michael Ong, Jeannie McLaughlin, Milena Antimicrob Resist Infect Control Letter to the Editor Vancomycin resistant Enterococcus (VRE) colonized patients are likely to receive VRE targeted Gram-positive antibiotics and may not be de-escalated appropriately once final cultures are available. A retrospective cohort study was conducted in VRE-colonized and non-VRE colonized patients with Enterococcal bloodstream infections. Of 101 patients (n = 50 VRE-colonized; n = 51 non-colonized), empiric therapy with linezolid or daptomycin was started more often in VRE-colonized than non-colonized patients (n = 8, 15.5% vs n = 27, 54%, p < 0.01). There was no difference in de-escalation once VRE infection was ruled out (non-colonized, n = 2, 66.7% vs VRE-colonized, n = 2, 50%, p = 0.09). This study encourages continued stewardship vigilance to decrease inappropriate antibiotic use. BioMed Central 2014-12-01 /pmc/articles/PMC4322851/ /pubmed/25671098 http://dx.doi.org/10.1186/2047-2994-3-37 Text en © Short et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Short, Elizabeth
Esterly, John
Postelnick, Michael
Ong, Jeannie
McLaughlin, Milena
Disposition of linezolid or daptomycin in Enterococcal bloodstream infections according to vancomycin resistant Enterococcus colonization
title Disposition of linezolid or daptomycin in Enterococcal bloodstream infections according to vancomycin resistant Enterococcus colonization
title_full Disposition of linezolid or daptomycin in Enterococcal bloodstream infections according to vancomycin resistant Enterococcus colonization
title_fullStr Disposition of linezolid or daptomycin in Enterococcal bloodstream infections according to vancomycin resistant Enterococcus colonization
title_full_unstemmed Disposition of linezolid or daptomycin in Enterococcal bloodstream infections according to vancomycin resistant Enterococcus colonization
title_short Disposition of linezolid or daptomycin in Enterococcal bloodstream infections according to vancomycin resistant Enterococcus colonization
title_sort disposition of linezolid or daptomycin in enterococcal bloodstream infections according to vancomycin resistant enterococcus colonization
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322851/
https://www.ncbi.nlm.nih.gov/pubmed/25671098
http://dx.doi.org/10.1186/2047-2994-3-37
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AT ongjeannie dispositionoflinezolidordaptomycininenterococcalbloodstreaminfectionsaccordingtovancomycinresistantenterococcuscolonization
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