Cargando…

Anti-inflammatory, antiangiogenic, and apoptosis-inducing activity of DLBS1442, a bioactive fraction of Phaleria macrocarpa, in a RL95-2 cell line as a molecular model of endometriosis

DLBS1442 is a bioactive fraction extracted from the fruit of the native Indonesian plant, Phaleria macrocarpa (Scheff.) Boerl (Thymelaceae). This bioactive fraction is a potential treatment for dysmenorrhea and endometriosis. The present study investigated the pharmacological action of DLBS1442 in e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tandrasasmita, Olivia M, Sutanto, Adeline M, Arifin, Poppy F, Tjandrawinata, Raymond R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322889/ https://www.ncbi.nlm.nih.gov/pubmed/25678821 http://dx.doi.org/10.2147/IJWH.S74552

Ejemplares similares

Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea with DLBS1442, a bioactive extract of Phaleria macrocarpa
por: Tjandrawinata, Raymond R, et al.
Publicado: (2011)

Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract
por: Karsono, Agung H, et al.
Publicado: (2021)

Bioactive fraction from Lagerstroemia speciosa leaves (DLBS3733) reduces fat droplet by inhibiting adipogenesis and lipogenesis
por: Karsono, Agung Heru, et al.
Publicado: (2019)

Molecular effects of bioactive fraction of Curcuma mangga (DLBS4847) as a downregulator of 5α-reductase activity pathways in prostatic epithelial cells
por: Karsono, Agung Heru, et al.
Publicado: (2014)

Hydrogen potassium adenosine triphosphatase activity inhibition and downregulation of its expression by bioactive fraction DLBS2411 from Cinnamomum burmannii in gastric parietal cells
por: Tjandrawinata, Raymond R, et al.
Publicado: (2013)

Effect of Phaleria macrocarpa on sexual function of rats
por: Parhizkar, Saadat, et al.
Publicado: (2013)

Phytochemical characteristics from Phaleria macrocarpa and its inhibitory activity on the peritoneal damage of endometriosis
por: Maharani, Maharani, et al.
Publicado: (2021)

Glucose-lowering effect of DLBS3233 is mediated through phosphorylation of tyrosine and upregulation of PPARγ and GLUT4 expression
por: Tandrasasmita, Olivia Mayasari, et al.
Publicado: (2011)

Phytochemistry and medicinal properties of Phaleria macrocarpa (Scheff.) Boerl. extracts
por: Altaf, Rabia, et al.
Publicado: (2013)

Bioassay-Guided Antidiabetic Study of Phaleria macrocarpa Fruit Extract
por: Ali, Rabyah B., et al.
Publicado: (2012)

Antioxidant, Anti-inflammatory and Cytotoxicity of Phaleria macrocarpa (Boerl.) Scheff Fruit
por: Hendra, Rudi, et al.
Publicado: (2011)

Antioxidants, Phytochemicals, and Cytotoxicity Studies on Phaleria macrocarpa (Scheff.) Boerl Seeds
por: Lay, Ma Ma, et al.
Publicado: (2014)

Protective Effect of Phaleria macrocarpa Water Extract (Proliverenol) against Carbon Tetrachloride-Induced Liver Fibrosis in Rats: Role of TNF-α and TGF-β1
por: Sundari, Nanik, et al.
Publicado: (2018)

Flavonoid Analyses and Antimicrobial Activity of Various Parts of Phaleria macrocarpa (Scheff.) Boerl Fruit
por: Hendra, Rudi, et al.
Publicado: (2011)

Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract
por: Parhizkar, Saadat, et al.
Publicado: (2014)

Effect of Phaleria Macrocarpa (Scheff.) Boerl Leaf Ethanol Extract on Serum IL-6 and TNF-α Levels in Diabetic Rats
por: Lestari, Ira Cinta, et al.
Publicado: (2023)

Gastroprotective Effect of DLBS2411 Bioactive Fraction from Cinnamomum burmannii Against Ethanol-Induced Gastric Damage in Rats
por: Tjandrawinata, Raymond R, et al.
Publicado: (2020)

Comparative Study of Antiproliferative Activity in Different Plant Parts of Phaleria macrocarpa and the Underlying Mechanism of Action
por: Christina, Yuyun Ika, et al.
Publicado: (2022)

Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques
por: Ahmad, Rosliza, et al.
Publicado: (2023)

Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa
por: Manaf, Asman, et al.
Publicado: (2016)

Antidiarrheal Effect of DLBS1Y62, a Bioactive Fraction of Uncaria gambir Roxb. Dried Sap Extract, in Wistar Rats
por: Wibowo, Dicky A, et al.
Publicado: (2021)

In vitro and in vivo effects of standardized extract and fractions of Phaleria macrocarpa fruits pericarp on lead carbohydrate digesting enzymes
por: Ali, Rabyah B, et al.
Publicado: (2013)

Rapid investigation of α-glucosidase inhibitory activity of Phaleria macrocarpa extracts using FTIR-ATR based fingerprinting
por: Easmin, Sabina, et al.
Publicado: (2016)

Angiotensin converting enzyme (ACE) inhibitors activity from purified compounds Fructus Phaleria macrocarpa (Scheff) Boerl
por: Eff, Aprilita Rina Yanti, et al.
Publicado: (2023)

Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lumbricus rubellus: ex vivo, in vivo, and pharmaceutic studies
por: Tjandrawinata, Raymond R, et al.
Publicado: (2014)

Phytochemical constituents, nutritional values, phenolics, flavonols, flavonoids, antioxidant and cytotoxicity studies on Phaleria macrocarpa (Scheff.) Boerl fruits
por: Lay, Ma Ma, et al.
Publicado: (2014)

Development of Phaleria macrocarpa (Scheff.) Boerl Fruits Using Response Surface Methodology Focused on Phenolics, Flavonoids and Antioxidant Properties
por: Mohamed Mahzir, Khurul Ain, et al.
Publicado: (2018)

DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic and Thrombolytic Activities
por: Trisina, Jessica, et al.
Publicado: (2011)

The Effect and Safety Assessment of Metformin and DLBS3233 (A Bioactive Fraction of Lagerstroemia speciosa and Cinnamomum burmannii) on Improving Metabolic Parameters in Women with Polycystic Ovary Syndrome
por: Hidayat, Syarief Thaufik, et al.
Publicado: (2023)

Effect of Temperatures on Drying Kinetics, Extraction Yield, Phenolics, Flavonoids, and Antioxidant Activity of Phaleria macrocarpa (Scheff.) Boerl. (Mahkota Dewa) Fruits
por: Stephenus, Fatin Nurain, et al.
Publicado: (2023)

Improvement in Pharmacological Activity of Mahkota Dewa (Phaleria macrocarpa (Schef. Boerl)) Seed Extracts in Nanoemulsion Dosage Form: In vitro and In vivo Studies
por: Agustin, Eriska, et al.
Publicado: (2023)

Effect of DLBS1033 on Functional Outcomes for Patients with Acute Ischemic Stroke: A Randomized Controlled Trial
por: Pinzon, Rizaldy Taslim, et al.
Publicado: (2021)

Potential Activity of Fevicordin-A from Phaleria macrocarpa (Scheff) Boerl. Seeds as Estrogen Receptor Antagonist Based on Cytotoxicity and Molecular Modelling Studies
por: Muchtaridi, Muchtaridi, et al.
Publicado: (2014)

Phaleria macrocarpa Boerl. (Thymelaeaceae) Leaves Increase SR-BI Expression and Reduce Cholesterol Levels in Rats Fed a High Cholesterol Diet
por: Andriani, Yosie, et al.
Publicado: (2015)

Effect of Phaleria Macrocarpa Flesh Fruits Extract on MDA Level, SGOT and SGPT Activity in Serum of Experimental Rats Contaminated by Cd (II) Ion
por: Nasution, Ali Napiah, et al.
Publicado: (2019)

In Vitro, In Silico and Network Pharmacology Mechanistic Approach to Investigate the α-Glucosidase Inhibitors Identified by Q-ToF-LCMS from Phaleria macrocarpa Fruit Subcritical CO(2) Extract
por: Mia, Md. Abdur Rashid, et al.
Publicado: (2022)

The combination of Elephantopus scaber and Phaleria macrocarpa leaves extract promotes anticancer activity via downregulation of ER-α, Nrf2 and PI3K/AKT/mTOR pathway
por: Christina, Yuyun Ika, et al.
Publicado: (2022)

Sphenoid Sinus Diseases: A Review of 1,442 Patients
por: Fooanant, Supranee, et al.
Publicado: (2017)

L-arginine enhances cell proliferation and reduces apoptosis in human endometrial RL95-2 cells
por: Greene, Jonathan M, et al.
Publicado: (2013)

Anti-Proliferative Effects of Siegesbeckia orientalis Ethanol Extract on Human Endometrial RL-95 Cancer Cells
por: Chang, Chi-Chang, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_dpa21a742fga53eufnt2lufmpk