Cargando…

Afatinib circumvents multidrug resistance via dually inhibiting ATP binding cassette subfamily G member 2 in vitro and in vivo

Multidrug resistance (MDR) to chemotherapeutic drugs is a formidable barrier to the success of cancer chemotherapy. Expressions of ATP-binding cassette (ABC) transporters contribute to clinical MDR phenotype. In this study, we found that afatinib, a small molecule tyrosine kinase inhibitor (TKI) tar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xiao-kun, Kin Wah To, Kenneth, Huang, Li-yan, Xu, Jing-hong, Yang, Ke, Wang, Fang, Huang, Zhen-cong, Ye, Sheng, Fu, Li-wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322967/ https://www.ncbi.nlm.nih.gov/pubmed/25436978

Ejemplares similares

Afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting ATP binding cassette subfamily B member 1
por: Wang, Sheng-qi, et al.
Publicado: (2015)

Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance
por: KATHAWALA, RISHIL J., et al.
Publicado: (2014)

Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds
por: Ma, Shengchao, et al.
Publicado: (2020)

Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATP-binding cassette subfamily G member 2 in vitro and in vivo
por: Zhang, Zhiqiang, et al.
Publicado: (2018)

Regulation of ATP‐binding cassette subfamily B member 1 by Snail contributes to chemoresistance in colorectal cancer
por: Wang, Hao, et al.
Publicado: (2019)

ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel
por: Kathawala, Rishil J, et al.
Publicado: (2015)

The expression and prognostic value of transporter 1, ATP binding cassette subfamily B member in clear cell renal cell cancer with experimental validation
por: Wang, Zhen-Da, et al.
Publicado: (2022)

Influence of (ATP)-Binding Cassette Transporter Subfamily B Member 1 (ABCB1) Gene Polymorphism on the Efficacy of Remifentanil
por: Wang, Wenzhu, et al.
Publicado: (2019)

Expression of ATP-binding cassette subfamily B member 1 gene in peripheral blood of patients with acute myocardial infarction
por: Ruan, Jianjun, et al.
Publicado: (2022)

ATP Binding Cassette Subfamily A Member 2 (ABCA2) Expression and Methylation are Associated with Alzheimer’s Disease
por: Hu, Wanhua, et al.
Publicado: (2017)

Bioinformatics Analysis of the Expression of ATP Binding Cassette Subfamily C Member 3 (ABCC3) in Human Glioma
por: Sun, Zelin, et al.
Publicado: (2020)

The role of ATP-binding cassette subfamily A in the etiology of Alzheimer’s disease
por: Bossaerts, Liene, et al.
Publicado: (2022)

NVP-CGM097, an HDM2 Inhibitor, Antagonizes ATP-Binding Cassette Subfamily B Member 1-Mediated Drug Resistance
por: Zhang, Meng, et al.
Publicado: (2020)

ATP binding cassette subfamily B member 9 (ABCB9) is a prognostic indicator of overall survival in ovarian cancer
por: Hou, Lin, et al.
Publicado: (2019)

sATP-binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells
por: Wu, Shaoxuan, et al.
Publicado: (2020)

Clinical Significance and Potential Mechanisms of ATP Binding Cassette Subfamily C Genes in Hepatocellular Carcinoma
por: Zhou, Xin, et al.
Publicado: (2022)

The Role of ATP-Binding Cassette Subfamily A in Colorectal Cancer Progression and Resistance
por: Alketbi, Latifa, et al.
Publicado: (2023)

Upregulation of ATP Binding Cassette Subfamily C Member 5 facilitates Prostate Cancer progression and Enzalutamide resistance via the CDK1-mediated AR Ser81 Phosphorylation Pathway
por: Ji, Guangjie, et al.
Publicado: (2021)

The R219K Polymorphism of the ATP Binding Cassette Subfamily a Member 1 Gene and Susceptibility to Ischemic Stroke in Chinese Population
por: Li, Jianmin, et al.
Publicado: (2020)

A 20(S)-protopanoxadiol derivative overcomes multi-drug resistance by antagonizing ATP-binding cassette subfamily B member 1 transporter function
por: Chen, Gang, et al.
Publicado: (2016)

Downregulation of ATP binding cassette subfamily a member 10 acts as a prognostic factor associated with immune infiltration in breast cancer
por: Chu, Pei-Yi, et al.
Publicado: (2022)

Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity
por: Marcantoni, Emanuela, et al.
Publicado: (2018)

The classification of ATP‐binding cassette subfamily A member 3 mutations using the cystic fibrosis transmembrane conductance regulator classification system
por: Denman, Laura, et al.
Publicado: (2018)

A pan-cancer analysis of the oncogenic role of ATP binding cassette subfamily E member 1 (ABCE1) in human tumors: An observational study
por: Yu, Jihong, et al.
Publicado: (2022)

Downregulated let-7d positively stimulates rectum adenocarcinoma cell malignant biological behaviors by upregulating ATP binding cassette subfamily C member 2
por: Liu, Zhen-Ji, et al.
Publicado: (2019)

Prognostic significance and molecular mechanisms of adenosine triphosphate-binding cassette subfamily C members in gastric cancer
por: Mao, Xianshuang, et al.
Publicado: (2019)

Prognostic Significance and Molecular Mechanism of ATP-Binding Cassette Subfamily C Member 4 in Resistance to Neoadjuvant Radiotherapy of Locally Advanced Rectal Carcinoma
por: Yu, Zhiqi, et al.
Publicado: (2014)

Promyelocytic leukemia zinc finger triggers ATP-binding cassette subfamily E member 1-mediated growth inhibition in breast cancer cells
por: Suliman, Bandar A., et al.
Publicado: (2018)

Use of ATP-Binding Cassette Subfamily A Member 13 (ABCA13) for Sensitive Detection of Focal Pathological Forms of Subclinical Bovine Paratuberculosis
por: Blanco-Vázquez, Cristina, et al.
Publicado: (2022)

Clinical and Genetic Analysis of a Family With Sitosterolemia Caused by a Novel ATP-Binding Cassette Subfamily G Member 5 Compound Heterozygous Mutation
por: Shen, Ming-fang, et al.
Publicado: (2022)

Varied clinical significance of ATP-binding cassette C sub-family members for lung adenocarcinoma
por: Zhang, Linbo, et al.
Publicado: (2021)

Loss of G protein pathway suppressor 2 in human adipocytes triggers lipid remodeling by upregulating ATP binding cassette subfamily G member 1
por: Barilla, Serena, et al.
Publicado: (2020)

CircFoxo3 Promotes Adriamycin Resistance Through Regulation of miR-199a-5p/ATP Binding Cassette Subfamily C Member 1 Axis in Hepatocellular Carcinoma
por: Huang, Wei, et al.
Publicado: (2020)

The Mutation Spectrum of Rare Variants in the Gene of Adenosine Triphosphate (ATP)-Binding Cassette Subfamily C Member 8 in Patients with a MODY Phenotype in Western Siberia
por: Ivanoshchuk, Dinara, et al.
Publicado: (2023)

Adenosine triphosphate-binding cassette subfamily C members in liver hepatocellular carcinoma: Bioinformatics-driven prognostic value
por: Meng, Xiangtong, et al.
Publicado: (2022)

Stemness and anti‐cancer drug resistance in ATP‐binding cassette subfamily G member 2 highly expressed pancreatic cancer is induced in 3D culture conditions
por: Sasaki, Norihiko, et al.
Publicado: (2018)

Upregulation of Chemoresistance by Mg(2+) Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells
por: Onuma, Saki, et al.
Publicado: (2021)

Genome-wide identification of ATP-binding cassette transporter B subfamily, focusing on its structure, evolution and rearrangement in ciliates
por: Zhang, Xue, et al.
Publicado: (2023)

A Regulator Role for the ATP-Binding Cassette Subfamily C Member 6 Transporter in HepG2 Cells: Effect on the Dynamics of Cell–Cell and Cell–Matrix Interactions
por: Matera, Ilenia, et al.
Publicado: (2023)

A novel epigenetic marker, Ten-eleven translocation family member 2 (TET2), is identified in the intractable epileptic brain and regulates ATP binding cassette subfamily B member 1 (ABCB1) in the blood–brain barrier
por: Kong, Fan-Cheng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2f5flglam70tussdc87q8m282d