GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis

Rhabdomyosarcoma (RMS) typically arises from skeletal muscle. Currently, RMS in patients with recurrent and metastatic disease have no successful treatment. The molecular pathogenesis of RMS varies based on cancer sub-types. Some embryonal RMS but not other sub-types are driven by sonic hedgehog (Sh...

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Detalles Bibliográficos
Autores principales: Srivastava, Ritesh K., Kaylani, Samer Zaid, Edrees, Nayf, Li, Changzhao, Talwelkar, Sarang S., Xu, Jianmin, Palle, Komaraiah, Pressey, Joseph G., Athar, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322980/
https://www.ncbi.nlm.nih.gov/pubmed/25432075

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