Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomas

Homozygous knockout of p53 in mice leads to early mortality from lymphoma, with almost complete penetrance, thus hampering studies of other tumor histotypes related to p53 alterations. To avoid lymphoma development, we crossed p53 knockout mice (BALB-p53 mice) with alymphocytic BALB/c Rag2(−/−);Il2r...

Descripción completa

Detalles Bibliográficos
Autores principales: Landuzzi, Lorena, Ianzano, Marianna L., Nicoletti, Giordano, Palladini, Arianna, Grosso, Valentina, Ranieri, Dario, Dall'Ora, Massimiliano, Raschi, Elena, Laranga, Roberta, Gambarotti, Marco, Picci, Piero, De Giovanni, Carla, Nanni, Patrizia, Lollini, Pier-Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322986/
https://www.ncbi.nlm.nih.gov/pubmed/25426555

Ejemplares similares

Ejemplares similares