Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides

[Image: see text] Several benzoxazocenones have been found to exhibit novel cellular activities. In the present study, we report a gold(I)-catalyzed 8-endo-dig hydroalkoxylation reaction of alkynamides to access analogous oxazocenone scaffolds. This methodology provided an advanced intermediate, whi...

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Autores principales: Scully, Stephen S., Zheng, Shao-Liang, Wagner, Bridget K., Schreiber, Stuart L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323038/
https://www.ncbi.nlm.nih.gov/pubmed/25569027
http://dx.doi.org/10.1021/ol503273v
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author Scully, Stephen S.
Zheng, Shao-Liang
Wagner, Bridget K.
Schreiber, Stuart L.
author_facet Scully, Stephen S.
Zheng, Shao-Liang
Wagner, Bridget K.
Schreiber, Stuart L.
author_sort Scully, Stephen S.
collection PubMed
description [Image: see text] Several benzoxazocenones have been found to exhibit novel cellular activities. In the present study, we report a gold(I)-catalyzed 8-endo-dig hydroalkoxylation reaction of alkynamides to access analogous oxazocenone scaffolds. This methodology provided an advanced intermediate, which was elaborated to a des-benzo analog of a bioactive benzoxazocenone.
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spelling pubmed-43230382016-01-08 Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides Scully, Stephen S. Zheng, Shao-Liang Wagner, Bridget K. Schreiber, Stuart L. Org Lett [Image: see text] Several benzoxazocenones have been found to exhibit novel cellular activities. In the present study, we report a gold(I)-catalyzed 8-endo-dig hydroalkoxylation reaction of alkynamides to access analogous oxazocenone scaffolds. This methodology provided an advanced intermediate, which was elaborated to a des-benzo analog of a bioactive benzoxazocenone. American Chemical Society 2015-01-08 2015-02-06 /pmc/articles/PMC4323038/ /pubmed/25569027 http://dx.doi.org/10.1021/ol503273v Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Scully, Stephen S.
Zheng, Shao-Liang
Wagner, Bridget K.
Schreiber, Stuart L.
Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides
title Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides
title_full Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides
title_fullStr Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides
title_full_unstemmed Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides
title_short Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides
title_sort synthesis of oxazocenones via gold(i)-catalyzed 8-endo-dig hydroalkoxylation of alkynamides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323038/
https://www.ncbi.nlm.nih.gov/pubmed/25569027
http://dx.doi.org/10.1021/ol503273v
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