Wnt versus Hippo: A balanced act or dynamic duo?

The Hippo signaling pathway was first discovered in Drosophila as a conserved regulator of organ size. Genetic inactivation in mice demonstrates that the Hippo pathway functions as a fundamental inhibitor of organ growth during development, and as a critical tumor suppressor in epithelial tissues.

Detalles Bibliográficos
Autores principales: Wang, Zhongliang, Ye, Jixing, Deng, Youlin, Yan, Zhengjian, Denduluri, Sahitya, He, Tong-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323082/
https://www.ncbi.nlm.nih.gov/pubmed/25679015
http://dx.doi.org/10.1016/j.gendis.2014.09.001
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author Wang, Zhongliang
Ye, Jixing
Deng, Youlin
Yan, Zhengjian
Denduluri, Sahitya
He, Tong-Chuan
author_facet Wang, Zhongliang
Ye, Jixing
Deng, Youlin
Yan, Zhengjian
Denduluri, Sahitya
He, Tong-Chuan
author_sort Wang, Zhongliang
collection PubMed
description The Hippo signaling pathway was first discovered in Drosophila as a conserved regulator of organ size. Genetic inactivation in mice demonstrates that the Hippo pathway functions as a fundamental inhibitor of organ growth during development, and as a critical tumor suppressor in epithelial tissues.
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spelling pubmed-43230822015-02-10 Wnt versus Hippo: A balanced act or dynamic duo? Wang, Zhongliang Ye, Jixing Deng, Youlin Yan, Zhengjian Denduluri, Sahitya He, Tong-Chuan Genes Dis Article The Hippo signaling pathway was first discovered in Drosophila as a conserved regulator of organ size. Genetic inactivation in mice demonstrates that the Hippo pathway functions as a fundamental inhibitor of organ growth during development, and as a critical tumor suppressor in epithelial tissues. Chongqing Medical University 2014-09-16 /pmc/articles/PMC4323082/ /pubmed/25679015 http://dx.doi.org/10.1016/j.gendis.2014.09.001 Text en Copyright © 2014, Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Wang, Zhongliang
Ye, Jixing
Deng, Youlin
Yan, Zhengjian
Denduluri, Sahitya
He, Tong-Chuan
Wnt versus Hippo: A balanced act or dynamic duo?
title Wnt versus Hippo: A balanced act or dynamic duo?
title_full Wnt versus Hippo: A balanced act or dynamic duo?
title_fullStr Wnt versus Hippo: A balanced act or dynamic duo?
title_full_unstemmed Wnt versus Hippo: A balanced act or dynamic duo?
title_short Wnt versus Hippo: A balanced act or dynamic duo?
title_sort wnt versus hippo: a balanced act or dynamic duo?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323082/
https://www.ncbi.nlm.nih.gov/pubmed/25679015
http://dx.doi.org/10.1016/j.gendis.2014.09.001
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AT yanzhengjian wntversushippoabalancedactordynamicduo
AT dendulurisahitya wntversushippoabalancedactordynamicduo
AT hetongchuan wntversushippoabalancedactordynamicduo

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