Bone marrow stroma-derived PGE(2) protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death

BACKGROUND: B cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most common paediatric cancer. BCP-ALL blasts typically retain wild type p53, and are therefore assumed to rely on indirect measures to suppress transformation-induced p53 activity. We have recently demonstrated that the sec...

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Detalles Bibliográficos
Autores principales: Naderi, Elin Hallan, Skah, Seham, Ugland, Hege, Myklebost, Ola, Sandnes, Dagny Lise, Torgersen, Maria Lyngaas, Josefsen, Dag, Ruud, Ellen, Naderi, Soheil, Blomhoff, Heidi Kiil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323193/
https://www.ncbi.nlm.nih.gov/pubmed/25623255
http://dx.doi.org/10.1186/s12943-014-0278-9

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