Sequence and structural determinants of human APOBEC3H deaminase and anti-HIV-1 activities

BACKGROUND: Human APOBEC3H (A3H) belongs to the A3 family of host restriction factors, which are cytidine deaminases that catalyze conversion of deoxycytidine to deoxyuridine in single-stranded DNA. A3 proteins contain either one (A3A, A3C, A3H) or two (A3B, A3D, A3F, A3G) Zn-binding domains. A3H ha...

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Detalles Bibliográficos
Autores principales: Mitra, Mithun, Singer, Dustin, Mano, Yu, Hritz, Jozef, Nam, Gabriel, Gorelick, Robert J, Byeon, In-Ja L, Gronenborn, Angela M, Iwatani, Yasumasa, Levin, Judith G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323217/
https://www.ncbi.nlm.nih.gov/pubmed/25614027
http://dx.doi.org/10.1186/s12977-014-0130-8

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