Cargando…

Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders

Inappropriate T cell responses in the central nervous system (CNS) affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include, but are not limited to, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson’s disease. On th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anderson, Kristi M, Olson, Katherine E, Estes, Katherine A, Flanagan, Ken, Gendelman, Howard E, Mosley, R Lee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323229/ https://www.ncbi.nlm.nih.gov/pubmed/25671101 http://dx.doi.org/10.1186/2047-9158-3-25

Ejemplares similares

Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders
por: Machhi, Jatin, et al.
Publicado: (2020)

Humanized Mice for Infectious and Neurodegenerative disorders
por: Dash, Prasanta K., et al.
Publicado: (2021)

Therapeutic Strategies for Immune Transformation in Parkinson’s Disease
por: Saleh, Maamoon, et al.
Publicado: (2022)

Prodrug Therapies for Infectious and Neurodegenerative Diseases
por: Markovic, Milica, et al.
Publicado: (2022)

An open-label multiyear study of sargramostim-treated Parkinson’s disease patients examining drug safety, tolerability, and immune biomarkers from limited case numbers
por: Olson, Katherine E., et al.
Publicado: (2023)

Immune mechanisms in neurological disorders: protective or destructive?
por: Minton, Kirsty
Publicado: (2001)

Immunotherapy for Parkinson’s disease
por: Schwab, Aaron D., et al.
Publicado: (2020)

Interleukin-2 expands neuroprotective regulatory T cells in Parkinson’s disease
por: Markovic, Milica, et al.
Publicado: (2022)

Monocyte biomarkers define sargramostim treatment outcomes for Parkinson's disease
por: Abdelmoaty, Mai M., et al.
Publicado: (2022)

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice
por: Banerjee, Rebecca, et al.
Publicado: (2008)

Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage Interactions
por: Abdelmoaty, Mai M., et al.
Publicado: (2021)

Safety, tolerability, and immune-biomarker profiling for year-long sargramostim treatment of Parkinson's disease
por: Olson, Katherine E., et al.
Publicado: (2021)

A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson’s Disease
por: Mosley, R. Lee, et al.
Publicado: (2019)

Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson’s disease
por: Schutt, Charles R., et al.
Publicado: (2018)

Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases
por: Haney, Matthew J., et al.
Publicado: (2013)

Multidimensional protein fractionation using ProteomeLab PF 2D™ for profiling amyotrophic lateral sclerosis immunity: A preliminary report
por: Schlautman, Joshua D, et al.
Publicado: (2008)

Propagation of TDP-43 proteinopathy in neurodegenerative disorders
por: Keszycki, Rachel, et al.
Publicado: (2021)

History of Innate Immunity in Neurodegenerative Disorders
por: McGeer, Patrick L., et al.
Publicado: (2011)

Neuromagnetic Evidence of Abnormal Movement-Related Beta Desynchronization in Parkinson's Disease
por: Heinrichs-Graham, Elizabeth, et al.
Publicado: (2014)

Insights into the protective role of immunity in neurodegenerative disease
por: Comi, Cristoforo, et al.
Publicado: (2017)

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?
por: Mayne, Katie, et al.
Publicado: (2020)

Does immune destruction drive all forms of bone marrow failure?
por: Dulmovits, Brian M., et al.
Publicado: (2022)

Neurodegenerative diseases as proteinopathies-driven immune disorders
por: Ciccocioppo, Fausta, et al.
Publicado: (2019)

Evaluation of the safety and immunomodulatory effects of sargramostim in a randomized, double-blind phase 1 clinical Parkinson’s disease trial
por: Gendelman, Howard E., et al.
Publicado: (2017)

Dual-Peak Lorentzian CEST MRI for antiretroviral drug brain distribution
por: Liu, Yutong, et al.
Publicado: (2023)

The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases
por: DeMaio, Alexa, et al.
Publicado: (2022)

Immune senescence in aged APP/PS1 mice
por: Abdelmoaty, Mai M., et al.
Publicado: (2023)

Sortilin inhibition treats multiple neurodegenerative lysosomal storage disorders
por: Leppert, Hannah G., et al.
Publicado: (2023)

A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy
por: Araínga, Mariluz, et al.
Publicado: (2017)

A New Generation of IMiDs as Treatments for Neuroinflammatory and Neurodegenerative Disorders
por: Kopp, Katherine O., et al.
Publicado: (2023)

Lipid Droplets in Neurodegenerative Disorders
por: Farmer, Brandon C., et al.
Publicado: (2020)

Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders
por: Behl, Tapan, et al.
Publicado: (2022)

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons
por: Benner, Eric J., et al.
Publicado: (2008)

Database of neurodegenerative disorders
por: Gowthaman, Ragul, et al.
Publicado: (2007)

Neuroregeneration in neurodegenerative disorders
por: Enciu, Ana M, et al.
Publicado: (2011)

Autophagy and neurodegenerative disorders
por: Kesidou, Evangelia, et al.
Publicado: (2013)

Ageing and Neurodegenerative Disorders
por: Piccardi, Laura, et al.
Publicado: (2015)

Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders
por: Koyiparambath, Vishal Payyalot, et al.
Publicado: (2021)

CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease
por: Saunders, Jessica A. Hutter, et al.
Publicado: (2012)

Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders
por: Covarrubias-Pinto, Adriana, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kejonkahfjkp6m2rmtpqkiis3k