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Examination of Candidate Exonic Variants for Association to Alzheimer Disease in the Amish

Alzheimer disease (AD) is the most common cause of dementia. As with many complex diseases, the identified variants do not explain the total expected genetic risk that is based on heritability estimates for AD. Isolated founder populations, such as the Amish, are advantageous for genetic studies as...

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Detalles Bibliográficos
Autores principales: D’Aoust, Laura N., Cummings, Anna C., Laux, Renee, Fuzzell, Denise, Caywood, Laura, Reinhart-Mercer, Lori, Scott, William K., Pericak-Vance, Margaret A., Haines, Jonathan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323242/
https://www.ncbi.nlm.nih.gov/pubmed/25668194
http://dx.doi.org/10.1371/journal.pone.0118043