The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations

BACKGROUND: Neuromyelitis optica (NMO) is a severe demyelinating disorder of the central nervous system (CNS) associated with the presence of an autoimmune antibody response (AQP4-IgG) against the water channel aquaporin-4 (AQP4). It remains unclear whether pathologic AQP4-IgG in the CNS is produced...

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Detalles Bibliográficos
Autores principales: Kowarik, Markus C, Dzieciatkowska, Monika, Wemlinger, Scott, Ritchie, Alanna M, Hemmer, Bernhard, Owens, Gregory P, Bennett, Jeffrey L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323273/
https://www.ncbi.nlm.nih.gov/pubmed/25626447
http://dx.doi.org/10.1186/s12974-015-0240-9

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