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Association between Statin Use and Cancer: Data Mining of a Spontaneous Reporting Database and a Claims Database

Purpose: In recent years, the potential risk of cancer associated with statin use has been a focus of much interest. However, it remains uncertain whether statin therapy is associated with cancer risk. To examine the association between statin use and the risk of cancer, we conducted data mining usi...

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Autores principales: Fujimoto, Mai, Higuchi, Tomoya, Hosomi, Kouichi, Takada, Mitsutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323360/
https://www.ncbi.nlm.nih.gov/pubmed/25678839
http://dx.doi.org/10.7150/ijms.10656
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author Fujimoto, Mai
Higuchi, Tomoya
Hosomi, Kouichi
Takada, Mitsutaka
author_facet Fujimoto, Mai
Higuchi, Tomoya
Hosomi, Kouichi
Takada, Mitsutaka
author_sort Fujimoto, Mai
collection PubMed
description Purpose: In recent years, the potential risk of cancer associated with statin use has been a focus of much interest. However, it remains uncertain whether statin therapy is associated with cancer risk. To examine the association between statin use and the risk of cancer, we conducted data mining using the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) and a large organized database of claims constructed by a database vendor (The Japan Medical Data Center Co., Ltd, Tokyo, Japan [JMDC]). Methods: Relevant reports in the FAERS, which included data from the first quarter of 2004 through the end of 2012, were identified and analyzed. The reporting odds ratio (ROR) was used to detect spontaneous report signals and was calculated using the case/non-case method. Additionally, signals were detected via the information component (IC) using the IC025 metric. Furthermore, event sequence symmetry analysis (ESSA) was applied to identify the risk of cancer following treatment with statins over the period January 2005 to July 2013. Results: In the FAERS database analyses, significant signals for colorectal cancer and pancreatic cancer were found for statins as a class. In the ESSA, significant associations between statin use and colorectal cancer and pancreatic cancer were found, with adjusted sequence ratios (95% confidence intervals) of 1.20 (1.08-1.34) and 1.31 (1.13-1.53), respectively, at an interval of 48 months. Conclusions: Multi-methodological approaches using different algorithms and databases suggest that statin use is associated with an increased risk for colorectal cancer and pancreatic cancer.
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spelling pubmed-43233602015-02-12 Association between Statin Use and Cancer: Data Mining of a Spontaneous Reporting Database and a Claims Database Fujimoto, Mai Higuchi, Tomoya Hosomi, Kouichi Takada, Mitsutaka Int J Med Sci Research Paper Purpose: In recent years, the potential risk of cancer associated with statin use has been a focus of much interest. However, it remains uncertain whether statin therapy is associated with cancer risk. To examine the association between statin use and the risk of cancer, we conducted data mining using the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) and a large organized database of claims constructed by a database vendor (The Japan Medical Data Center Co., Ltd, Tokyo, Japan [JMDC]). Methods: Relevant reports in the FAERS, which included data from the first quarter of 2004 through the end of 2012, were identified and analyzed. The reporting odds ratio (ROR) was used to detect spontaneous report signals and was calculated using the case/non-case method. Additionally, signals were detected via the information component (IC) using the IC025 metric. Furthermore, event sequence symmetry analysis (ESSA) was applied to identify the risk of cancer following treatment with statins over the period January 2005 to July 2013. Results: In the FAERS database analyses, significant signals for colorectal cancer and pancreatic cancer were found for statins as a class. In the ESSA, significant associations between statin use and colorectal cancer and pancreatic cancer were found, with adjusted sequence ratios (95% confidence intervals) of 1.20 (1.08-1.34) and 1.31 (1.13-1.53), respectively, at an interval of 48 months. Conclusions: Multi-methodological approaches using different algorithms and databases suggest that statin use is associated with an increased risk for colorectal cancer and pancreatic cancer. Ivyspring International Publisher 2015-01-22 /pmc/articles/PMC4323360/ /pubmed/25678839 http://dx.doi.org/10.7150/ijms.10656 Text en © 2015 Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
spellingShingle Research Paper
Fujimoto, Mai
Higuchi, Tomoya
Hosomi, Kouichi
Takada, Mitsutaka
Association between Statin Use and Cancer: Data Mining of a Spontaneous Reporting Database and a Claims Database
title Association between Statin Use and Cancer: Data Mining of a Spontaneous Reporting Database and a Claims Database
title_full Association between Statin Use and Cancer: Data Mining of a Spontaneous Reporting Database and a Claims Database
title_fullStr Association between Statin Use and Cancer: Data Mining of a Spontaneous Reporting Database and a Claims Database
title_full_unstemmed Association between Statin Use and Cancer: Data Mining of a Spontaneous Reporting Database and a Claims Database
title_short Association between Statin Use and Cancer: Data Mining of a Spontaneous Reporting Database and a Claims Database
title_sort association between statin use and cancer: data mining of a spontaneous reporting database and a claims database
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323360/
https://www.ncbi.nlm.nih.gov/pubmed/25678839
http://dx.doi.org/10.7150/ijms.10656
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