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The Neuromodulation of Neuropathic Pain by Measuring Pain Response Rate and Pain Response Duration in Animal
OBJECTIVE: Neuropathic pain causes patients feel indescribable pain. Deep Brain Stimulation (DBS) is one of the treatment methods in neuropathic pain but the action mechanism is still unclear. To study the effect and mechanism of analgesic effects from DBS in neuropathic pain and to enhance the anal...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Neurosurgical Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323508/ https://www.ncbi.nlm.nih.gov/pubmed/25674337 http://dx.doi.org/10.3340/jkns.2015.57.1.6 |
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author | Kim, Jinhyung Lee, Sung Eun Shin, Jaewoo Jung, Hyun Ho Kim, Sung June Chang, Jin Woo |
author_facet | Kim, Jinhyung Lee, Sung Eun Shin, Jaewoo Jung, Hyun Ho Kim, Sung June Chang, Jin Woo |
author_sort | Kim, Jinhyung |
collection | PubMed |
description | OBJECTIVE: Neuropathic pain causes patients feel indescribable pain. Deep Brain Stimulation (DBS) is one of the treatment methods in neuropathic pain but the action mechanism is still unclear. To study the effect and mechanism of analgesic effects from DBS in neuropathic pain and to enhance the analgesic effect of DBS, we stimulated the ventral posterolateral nucleus (VPL) in rats. METHODS: To observe the effect from VPL stimulation, we established 3 groups : normal group (Normal group), neuropathic pain group (Pain group) and neuropathic pain+DBS group (DBS group). Rats in DBS group subjected to electrical stimulation and the target is VPL. RESULTS: We observed the behavioral changes by DBS in VPL (VPL-DBS) on neuropathic pain rats. In our study, the pain score which is by conventional test method was effectively decreased. In specific, the time of showing withdrawal response from painful stimulation which is not used measuring method in our animal model was also decreased by DBS. CONCLUSION: The VPL is an effective target on pain modulation. Specifically we could demonstrate changes of pain response duration which is not used, and it was also significantly meaningful. We thought that this study would be helpful in understanding the relation between VPL-DBS and neuropathic pain. |
format | Online Article Text |
id | pubmed-4323508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Neurosurgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-43235082015-02-11 The Neuromodulation of Neuropathic Pain by Measuring Pain Response Rate and Pain Response Duration in Animal Kim, Jinhyung Lee, Sung Eun Shin, Jaewoo Jung, Hyun Ho Kim, Sung June Chang, Jin Woo J Korean Neurosurg Soc Laboratory Investigation OBJECTIVE: Neuropathic pain causes patients feel indescribable pain. Deep Brain Stimulation (DBS) is one of the treatment methods in neuropathic pain but the action mechanism is still unclear. To study the effect and mechanism of analgesic effects from DBS in neuropathic pain and to enhance the analgesic effect of DBS, we stimulated the ventral posterolateral nucleus (VPL) in rats. METHODS: To observe the effect from VPL stimulation, we established 3 groups : normal group (Normal group), neuropathic pain group (Pain group) and neuropathic pain+DBS group (DBS group). Rats in DBS group subjected to electrical stimulation and the target is VPL. RESULTS: We observed the behavioral changes by DBS in VPL (VPL-DBS) on neuropathic pain rats. In our study, the pain score which is by conventional test method was effectively decreased. In specific, the time of showing withdrawal response from painful stimulation which is not used measuring method in our animal model was also decreased by DBS. CONCLUSION: The VPL is an effective target on pain modulation. Specifically we could demonstrate changes of pain response duration which is not used, and it was also significantly meaningful. We thought that this study would be helpful in understanding the relation between VPL-DBS and neuropathic pain. The Korean Neurosurgical Society 2015-01 2015-01-31 /pmc/articles/PMC4323508/ /pubmed/25674337 http://dx.doi.org/10.3340/jkns.2015.57.1.6 Text en Copyright © 2015 The Korean Neurosurgical Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Laboratory Investigation Kim, Jinhyung Lee, Sung Eun Shin, Jaewoo Jung, Hyun Ho Kim, Sung June Chang, Jin Woo The Neuromodulation of Neuropathic Pain by Measuring Pain Response Rate and Pain Response Duration in Animal |
title | The Neuromodulation of Neuropathic Pain by Measuring Pain Response Rate and Pain Response Duration in Animal |
title_full | The Neuromodulation of Neuropathic Pain by Measuring Pain Response Rate and Pain Response Duration in Animal |
title_fullStr | The Neuromodulation of Neuropathic Pain by Measuring Pain Response Rate and Pain Response Duration in Animal |
title_full_unstemmed | The Neuromodulation of Neuropathic Pain by Measuring Pain Response Rate and Pain Response Duration in Animal |
title_short | The Neuromodulation of Neuropathic Pain by Measuring Pain Response Rate and Pain Response Duration in Animal |
title_sort | neuromodulation of neuropathic pain by measuring pain response rate and pain response duration in animal |
topic | Laboratory Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323508/ https://www.ncbi.nlm.nih.gov/pubmed/25674337 http://dx.doi.org/10.3340/jkns.2015.57.1.6 |
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