Cell necrosis–independent sustained mitochondrial and nuclear DNA release following trauma surgery

BACKGROUND: Mitochondrial DNA (mtDNA), a potent proinflammatory damage-associated molecular pattern, is released in large titers following trauma. The effect of trauma surgery on mtDNA concentration is unknown. We hypothesized that mtDNA and nuclear DNA (nDNA) levels would increase proportionately w...

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Detalles Bibliográficos
Autores principales: McIlroy, Daniel J., Bigland, Mark, White, Amanda E., Hardy, Benjamin M., Lott, Natalie, Smith, Doug W., Balogh, Zsolt J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott, Williams & Wilkins 2015
Materias:
WTA 2014 Plenary Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323572/
https://www.ncbi.nlm.nih.gov/pubmed/25602756
http://dx.doi.org/10.1097/TA.0000000000000519

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