Down-Regulation of Human Enteric Antimicrobial Peptides by NOD2 during Differentiation of the Paneth Cell Lineage

Ileal Crohn's disease (CD) arising from the alteration of intestinal homeostasis is characterized by two features, namely a decrease in Paneth cell-produced antimicrobial peptides that play a key role in maintaining this balance and an increase in NOD2, an intracellular sensor. Although mutatio...

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Detalles Bibliográficos
Autores principales: Tan, Gao, Li, Run-hua, Li, Chen, Wu, Fang, Zhao, Xin-mei, Ma, Jia-yi, Lei, Shan, Zhang, Wen-di, Zhi, Fa-chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323657/
https://www.ncbi.nlm.nih.gov/pubmed/25670499
http://dx.doi.org/10.1038/srep08383

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