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Fitness Profiling Links Topoisomerase II Regulation of Centromeric Integrity to Doxorubicin Resistance in Fission Yeast

Doxorubicin, a chemotherapeutic agent, inhibits the religation step of topoisomerase II (Top2). However, the downstream ramifications of this action are unknown. Here we performed epistasis analyses of top2 with 63 genes representing doxorubicin resistance (DXR) genes in fission yeast and revealed a...

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Detalles Bibliográficos
Autores principales:	Nguyen, Thi Thuy Trang, Lim, Julia Sze Lynn, Tang, Richard Ming Yi, Zhang, Louxin, Chen, Ee Sin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323662/ https://www.ncbi.nlm.nih.gov/pubmed/25669599 http://dx.doi.org/10.1038/srep08400

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