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A Novel Method to Capture the Onset of Dynamic Electrocardiographic Ischemic Changes and its Implications to Arrhythmia Susceptibility
BACKGROUND: This study investigates the hypothesis that morphologic analysis of intracardiac electrograms provides a sensitive approach to detect acute myocardial infarction or myocardial infarction‐induced arrhythmia susceptibility. Large proportions of irreversible myocardial injury and fatal vent...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323775/ https://www.ncbi.nlm.nih.gov/pubmed/25187521 http://dx.doi.org/10.1161/JAHA.114.001055 |
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author | Sayadi, Omid Puppala, Dheeraj Ishaque, Nosheen Doddamani, Rajiv Merchant, Faisal M. Barrett, Conor Singh, Jagmeet P. Heist, E. Kevin Mela, Theofanie Martínez, Juan Pablo Laguna, Pablo Armoundas, Antonis A. |
author_facet | Sayadi, Omid Puppala, Dheeraj Ishaque, Nosheen Doddamani, Rajiv Merchant, Faisal M. Barrett, Conor Singh, Jagmeet P. Heist, E. Kevin Mela, Theofanie Martínez, Juan Pablo Laguna, Pablo Armoundas, Antonis A. |
author_sort | Sayadi, Omid |
collection | PubMed |
description | BACKGROUND: This study investigates the hypothesis that morphologic analysis of intracardiac electrograms provides a sensitive approach to detect acute myocardial infarction or myocardial infarction‐induced arrhythmia susceptibility. Large proportions of irreversible myocardial injury and fatal ventricular tachyarrhythmias occur in the first hour after coronary occlusion; therefore, early detection of acute myocardial infarction may improve clinical outcomes. METHODS AND RESULTS: We developed a method that uses the wavelet transform to delineate electrocardiographic signals, and we have devised an index to quantify the ischemia‐induced changes in these signals. We recorded body‐surface and intracardiac electrograms at baseline and following myocardial infarction in 24 swine. Statistically significant ischemia‐induced changes after the initiation of occlusion compared with baseline were detectable within 30 seconds in intracardiac left ventricle (P<0.0016) and right ventricle–coronary sinus (P<0.0011) leads, 60 seconds in coronary sinus leads (P<0.0002), 90 seconds in right ventricle leads (P<0.0020), and 360 seconds in body‐surface electrocardiographic signals (P<0.0022). Intracardiac leads exhibited a higher probability of detecting ischemia‐induced changes than body‐surface leads (P<0.0381), and the right ventricle–coronary sinus configuration provided the highest sensitivity (96%). The 24‐hour ECG recordings showed that the ischemic index is statistically significantly increased compared with baseline in lead I, aVR, and all precordial leads (P<0.0388). Finally, we showed that the ischemic index in intracardiac electrograms is significantly increased preceding ventricular tachyarrhythmic events (P<0.0360). CONCLUSIONS: We present a novel method that is capable of detecting ischemia‐induced changes in intracardiac electrograms as early as 30 seconds following myocardial infarction or as early as 12 minutes preceding tachyarrhythmic events. |
format | Online Article Text |
id | pubmed-4323775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43237752015-02-23 A Novel Method to Capture the Onset of Dynamic Electrocardiographic Ischemic Changes and its Implications to Arrhythmia Susceptibility Sayadi, Omid Puppala, Dheeraj Ishaque, Nosheen Doddamani, Rajiv Merchant, Faisal M. Barrett, Conor Singh, Jagmeet P. Heist, E. Kevin Mela, Theofanie Martínez, Juan Pablo Laguna, Pablo Armoundas, Antonis A. J Am Heart Assoc Original Research BACKGROUND: This study investigates the hypothesis that morphologic analysis of intracardiac electrograms provides a sensitive approach to detect acute myocardial infarction or myocardial infarction‐induced arrhythmia susceptibility. Large proportions of irreversible myocardial injury and fatal ventricular tachyarrhythmias occur in the first hour after coronary occlusion; therefore, early detection of acute myocardial infarction may improve clinical outcomes. METHODS AND RESULTS: We developed a method that uses the wavelet transform to delineate electrocardiographic signals, and we have devised an index to quantify the ischemia‐induced changes in these signals. We recorded body‐surface and intracardiac electrograms at baseline and following myocardial infarction in 24 swine. Statistically significant ischemia‐induced changes after the initiation of occlusion compared with baseline were detectable within 30 seconds in intracardiac left ventricle (P<0.0016) and right ventricle–coronary sinus (P<0.0011) leads, 60 seconds in coronary sinus leads (P<0.0002), 90 seconds in right ventricle leads (P<0.0020), and 360 seconds in body‐surface electrocardiographic signals (P<0.0022). Intracardiac leads exhibited a higher probability of detecting ischemia‐induced changes than body‐surface leads (P<0.0381), and the right ventricle–coronary sinus configuration provided the highest sensitivity (96%). The 24‐hour ECG recordings showed that the ischemic index is statistically significantly increased compared with baseline in lead I, aVR, and all precordial leads (P<0.0388). Finally, we showed that the ischemic index in intracardiac electrograms is significantly increased preceding ventricular tachyarrhythmic events (P<0.0360). CONCLUSIONS: We present a novel method that is capable of detecting ischemia‐induced changes in intracardiac electrograms as early as 30 seconds following myocardial infarction or as early as 12 minutes preceding tachyarrhythmic events. Blackwell Publishing Ltd 2014-09-03 /pmc/articles/PMC4323775/ /pubmed/25187521 http://dx.doi.org/10.1161/JAHA.114.001055 Text en © 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Sayadi, Omid Puppala, Dheeraj Ishaque, Nosheen Doddamani, Rajiv Merchant, Faisal M. Barrett, Conor Singh, Jagmeet P. Heist, E. Kevin Mela, Theofanie Martínez, Juan Pablo Laguna, Pablo Armoundas, Antonis A. A Novel Method to Capture the Onset of Dynamic Electrocardiographic Ischemic Changes and its Implications to Arrhythmia Susceptibility |
title | A Novel Method to Capture the Onset of Dynamic Electrocardiographic Ischemic Changes and its Implications to Arrhythmia Susceptibility |
title_full | A Novel Method to Capture the Onset of Dynamic Electrocardiographic Ischemic Changes and its Implications to Arrhythmia Susceptibility |
title_fullStr | A Novel Method to Capture the Onset of Dynamic Electrocardiographic Ischemic Changes and its Implications to Arrhythmia Susceptibility |
title_full_unstemmed | A Novel Method to Capture the Onset of Dynamic Electrocardiographic Ischemic Changes and its Implications to Arrhythmia Susceptibility |
title_short | A Novel Method to Capture the Onset of Dynamic Electrocardiographic Ischemic Changes and its Implications to Arrhythmia Susceptibility |
title_sort | novel method to capture the onset of dynamic electrocardiographic ischemic changes and its implications to arrhythmia susceptibility |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323775/ https://www.ncbi.nlm.nih.gov/pubmed/25187521 http://dx.doi.org/10.1161/JAHA.114.001055 |
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