Acute interstitial nephritis due to statin and its class effect

Recent reports indicate that statins can cause nephrotoxicity. However, the mechanisms of nephrotoxicity remain unclear. We report a case of acute kidney injury (AKI) in a 54-year-old man following the administration of atorvastatin Renal biopsy showed acute interstitial nephritis. Atorvastatin was...

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Detalles Bibliográficos
Autores principales: Annigeri, R. A., Mani, R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323914/
https://www.ncbi.nlm.nih.gov/pubmed/25684874
http://dx.doi.org/10.4103/0971-4065.136883
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author Annigeri, R. A.
Mani, R. M.
author_facet Annigeri, R. A.
Mani, R. M.
author_sort Annigeri, R. A.
collection PubMed
description Recent reports indicate that statins can cause nephrotoxicity. However, the mechanisms of nephrotoxicity remain unclear. We report a case of acute kidney injury (AKI) in a 54-year-old man following the administration of atorvastatin Renal biopsy showed acute interstitial nephritis. Atorvastatin was withdrawn and he was treated with corticosteroid following which renal function recovered. When he was rechallenged with rosuvastatin 6 months later following an episode of acute myocardial infarction, he developed AKI again indicating class effect of statin for nephrotoxicity.
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spelling pubmed-43239142015-02-13 Acute interstitial nephritis due to statin and its class effect Annigeri, R. A. Mani, R. M. Indian J Nephrol Case Report Recent reports indicate that statins can cause nephrotoxicity. However, the mechanisms of nephrotoxicity remain unclear. We report a case of acute kidney injury (AKI) in a 54-year-old man following the administration of atorvastatin Renal biopsy showed acute interstitial nephritis. Atorvastatin was withdrawn and he was treated with corticosteroid following which renal function recovered. When he was rechallenged with rosuvastatin 6 months later following an episode of acute myocardial infarction, he developed AKI again indicating class effect of statin for nephrotoxicity. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4323914/ /pubmed/25684874 http://dx.doi.org/10.4103/0971-4065.136883 Text en Copyright: © Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Annigeri, R. A.
Mani, R. M.
Acute interstitial nephritis due to statin and its class effect
title Acute interstitial nephritis due to statin and its class effect
title_full Acute interstitial nephritis due to statin and its class effect
title_fullStr Acute interstitial nephritis due to statin and its class effect
title_full_unstemmed Acute interstitial nephritis due to statin and its class effect
title_short Acute interstitial nephritis due to statin and its class effect
title_sort acute interstitial nephritis due to statin and its class effect
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323914/
https://www.ncbi.nlm.nih.gov/pubmed/25684874
http://dx.doi.org/10.4103/0971-4065.136883
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