Successful Treatment of Intracranial Hemorrhage with Recombinant Activated Factor VII in a Patient with Newly Diagnosed Acute Myeloid Leukemia: A Case Report and Review of the Literature

Intracranial hemorrhage (ICH) is a common complication in acute myeloid leukemia (AML) patients with an incidence rate of 6.3% (1). Bleeding disorders related to disseminated intravascular coagulation (DIC) are common complications in AML cases (2). Recombinant activated Factor VII [rFVIIa (NovoSeve...

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Autores principales: Pemmaraju, Naveen, Sasaki, Koji, Johnson, Daniel, Daver, Naval, Afshar-Kharghan, Vahid, Chen, Merry, Ahmed, Sairah, Colen, Rivka R., Kwon, Michael, Huh, Yang, Borthakur, Gautam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324079/
https://www.ncbi.nlm.nih.gov/pubmed/25717439
http://dx.doi.org/10.3389/fonc.2015.00029
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author Pemmaraju, Naveen
Sasaki, Koji
Johnson, Daniel
Daver, Naval
Afshar-Kharghan, Vahid
Chen, Merry
Ahmed, Sairah
Colen, Rivka R.
Kwon, Michael
Huh, Yang
Borthakur, Gautam
author_facet Pemmaraju, Naveen
Sasaki, Koji
Johnson, Daniel
Daver, Naval
Afshar-Kharghan, Vahid
Chen, Merry
Ahmed, Sairah
Colen, Rivka R.
Kwon, Michael
Huh, Yang
Borthakur, Gautam
author_sort Pemmaraju, Naveen
collection PubMed
description Intracranial hemorrhage (ICH) is a common complication in acute myeloid leukemia (AML) patients with an incidence rate of 6.3% (1). Bleeding disorders related to disseminated intravascular coagulation (DIC) are common complications in AML cases (2). Recombinant activated Factor VII [rFVIIa (NovoSeven(®))] is approved for the treatment of bleeding complications with FVIII or FIX inhibitors in patients with congenital FVII deficiency. Use of rFVIIa for the treatment of acute hemorrhage in patients without hemophilia has been successful (3, 4). Herein, we describe the successful use of rFVIIa in a patient with acute ICH in the setting of newly diagnosed AML.
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spelling pubmed-43240792015-02-25 Successful Treatment of Intracranial Hemorrhage with Recombinant Activated Factor VII in a Patient with Newly Diagnosed Acute Myeloid Leukemia: A Case Report and Review of the Literature Pemmaraju, Naveen Sasaki, Koji Johnson, Daniel Daver, Naval Afshar-Kharghan, Vahid Chen, Merry Ahmed, Sairah Colen, Rivka R. Kwon, Michael Huh, Yang Borthakur, Gautam Front Oncol Oncology Intracranial hemorrhage (ICH) is a common complication in acute myeloid leukemia (AML) patients with an incidence rate of 6.3% (1). Bleeding disorders related to disseminated intravascular coagulation (DIC) are common complications in AML cases (2). Recombinant activated Factor VII [rFVIIa (NovoSeven(®))] is approved for the treatment of bleeding complications with FVIII or FIX inhibitors in patients with congenital FVII deficiency. Use of rFVIIa for the treatment of acute hemorrhage in patients without hemophilia has been successful (3, 4). Herein, we describe the successful use of rFVIIa in a patient with acute ICH in the setting of newly diagnosed AML. Frontiers Media S.A. 2015-02-11 /pmc/articles/PMC4324079/ /pubmed/25717439 http://dx.doi.org/10.3389/fonc.2015.00029 Text en Copyright © 2015 Pemmaraju, Sasaki, Johnson, Daver, Afshar-Kharghan, Chen, Ahmed, Colen, Kwon, Huh and Borthakur. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Pemmaraju, Naveen
Sasaki, Koji
Johnson, Daniel
Daver, Naval
Afshar-Kharghan, Vahid
Chen, Merry
Ahmed, Sairah
Colen, Rivka R.
Kwon, Michael
Huh, Yang
Borthakur, Gautam
Successful Treatment of Intracranial Hemorrhage with Recombinant Activated Factor VII in a Patient with Newly Diagnosed Acute Myeloid Leukemia: A Case Report and Review of the Literature
title Successful Treatment of Intracranial Hemorrhage with Recombinant Activated Factor VII in a Patient with Newly Diagnosed Acute Myeloid Leukemia: A Case Report and Review of the Literature
title_full Successful Treatment of Intracranial Hemorrhage with Recombinant Activated Factor VII in a Patient with Newly Diagnosed Acute Myeloid Leukemia: A Case Report and Review of the Literature
title_fullStr Successful Treatment of Intracranial Hemorrhage with Recombinant Activated Factor VII in a Patient with Newly Diagnosed Acute Myeloid Leukemia: A Case Report and Review of the Literature
title_full_unstemmed Successful Treatment of Intracranial Hemorrhage with Recombinant Activated Factor VII in a Patient with Newly Diagnosed Acute Myeloid Leukemia: A Case Report and Review of the Literature
title_short Successful Treatment of Intracranial Hemorrhage with Recombinant Activated Factor VII in a Patient with Newly Diagnosed Acute Myeloid Leukemia: A Case Report and Review of the Literature
title_sort successful treatment of intracranial hemorrhage with recombinant activated factor vii in a patient with newly diagnosed acute myeloid leukemia: a case report and review of the literature
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324079/
https://www.ncbi.nlm.nih.gov/pubmed/25717439
http://dx.doi.org/10.3389/fonc.2015.00029
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